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Niklas Feldhahn
Researcher at Imperial College London
Publications - 41
Citations - 5969
Niklas Feldhahn is an academic researcher from Imperial College London. The author has contributed to research in topics: B cell & Leukemia. The author has an hindex of 22, co-authored 39 publications receiving 5510 citations. Previous affiliations of Niklas Feldhahn include University of Düsseldorf & Howard Hughes Medical Institute.
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Journal ArticleDOI
53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
Samuel F. Bunting,Elsa Callen,Nancy Wong,Hua Tang Chen,Federica Polato,Amanda Gunn,Anne Bothmer,Niklas Feldhahn,Oscar Fernandez-Capetillo,Liu Cao,Xiaoling Xu,Chu-Xia Deng,Toren Finkel,Michel C. Nussenzweig,Michel C. Nussenzweig,Jeremy M. Stark,André Nussenzweig +16 more
TL;DR: It is shown that DNA breaks in Brca1-deficient cells are aberrantly joined into complex chromosome rearrangements by a process dependent on the nonhomologous end-joining (NHEJ) factors 53BP1 and DNA ligase 4, illustrating that HR and NHEJ compete to process DNA breaks that arise during DNA replication.
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A New Human Somatic Stem Cell from Placental Cord Blood with Intrinsic Pluripotent Differentiation Potential
Gesine Kögler,Sandra Sensken,Judith A. Airey,Thorsten Trapp,Markus Müschen,Niklas Feldhahn,Stefanie Liedtke,Rüdiger V. Sorg,Johannes C. Fischer,Claudia Rosenbaum,Susanne Greschat,Andreas Knipper,Jörg Bender,Özer Degistirici,Jizong Gao,Arnold I. Caplan,Evan Colletti,Graça Almeida-Porada,Hans Werner Müller,Esmail D. Zanjani,Peter Wernet +20 more
TL;DR: A new, intrinsically pluripotent, CD45-negative population from human cord blood, termed unrestricted somatic stem cells (USSCs) is described, which grows adherently and can be expanded to 1015 cells without losing pluripotency.
Journal ArticleDOI
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
Johannes F. Scheid,Hugo Mouquet,Niklas Feldhahn,Michael S. Seaman,Klara Velinzon,John Pietzsch,Rene G. Ott,Robert M. Anthony,Henry Zebroski,Arlene Hurley,Adhuna Phogat,Bimal K. Chakrabarti,Yuxing Li,Mark Connors,Florencia Pereyra,Bruce D. Walker,Hedda Wardemann,David D. Ho,Richard T. Wyatt,John R. Mascola,Jeffrey V. Ravetch,Michel C. Nussenzweig +21 more
TL;DR: The IgG memory B-cell compartment in the selected group of patients with broad serumneutralizing activity to HIV is comprised of multiple clonal responses with neutralizing activity directed against several epitopes on gp120.
Journal ArticleDOI
Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
Michela Di Virgilio,Elsa Callen,Arito Yamane,Wenzhu Zhang,Mila Jankovic,Alexander D. Gitlin,Niklas Feldhahn,Wolfgang Resch,Thiago Y. Oliveira,Thiago Y. Oliveira,Thiago Y. Oliveira,Brian T. Chait,André Nussenzweig,Rafael Casellas,Davide F. Robbiani,Michel C. Nussenzweig,Michel C. Nussenzweig +16 more
TL;DR: Rap1-interacting factor 1 (Rif1) is identified as an ATM (ataxia-telangiectasia mutated) phosphorylation-dependent interactor of 53BP1 and it is shown that absence of Rif1 results in 5′-3′ DNA-end resection in mice.
Journal ArticleDOI
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
Anne Bothmer,Davide F. Robbiani,Niklas Feldhahn,Anna Gazumyan,André Nussenzweig,Michel C. Nussenzweig +5 more
TL;DR: It is proposed that 53BP1 favors long-range CSR in part by protecting DNA ends against resection, which prevents A-NHEJ–dependent short-range rejoining of intra–switch region DSBs.