P. Haffter

TL;DR: It is estimated that the 372 genes defined by the mutants probably represent more than half of all genes that could have been discovered using the criteria of the screen, and the limits and the potentials of a genetic saturation screen in the zebrafish.

TL;DR: Analysis of the behavioral defects suggests that these genes participate in the diverse locomotion patterns observed, such as touch response, rhythmic tail movements, equilibrium control, or that they simply confer general motility to the animal.

TL;DR: In this paper, two groups of mutants with defects in this patterning process have been isolated in a screen for zygotic mutations affecting the embryonic development of the zebrafish (Danio rerio).

TL;DR: It is demonstrated that it is feasible to screen for genes specific for the patterning or function of certain internal organs in the zebrafish and the mutations presented here could serve as an entry point to the establishment of a genetic hierarchy underlying organogenesis.

TL;DR: The similar and overlapping phenotypes of mutants of the 6 genes identified suggest that they function in a common pathway, which begins in oogenesis, but also depends on factors provided after the onset of zygotic transcription, presumably during blastula stages.