P
P. Reed Larsen
Researcher at Brigham and Women's Hospital
Publications - 167
Citations - 17218
P. Reed Larsen is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Deiodinase & Thyroid. The author has an hindex of 61, co-authored 166 publications receiving 16003 citations. Previous affiliations of P. Reed Larsen include Harvard University & Howard Hughes Medical Institute.
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Journal ArticleDOI
Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.
TL;DR: The goal of this review is to place the exciting advances that have occurred in understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3, respectively) iodothyronine deiodinases into a biochemical and physiological context.
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Management of thyroid nodules detected at US: Society of radiologists in ultrasound consensus conference statement
Mary C. Frates,Carol B. Benson,J. William Charboneau,Edmund S. Cibas,Orlo H. Clark,Beverly G. Coleman,John J. Cronan,Peter M. Doubilet,Douglas B. Evans,John R. Goellner,Ian D. Hay,Barbara S. Hertzberg,Charles M. Intenzo,R. Brooke Jeffrey,Jill E. Langer,P. Reed Larsen,Susan J. Mandel,William D. Middleton,Carl C. Reading,Steven I. Sherman,Franklin N. Tessler +20 more
TL;DR: The recommendations in this consensus statement, which are based on analysis of the current literature and common practice strategies, are thought to represent a reasonable approach to thyroid nodular disease.
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Type I iodothyronine deiodinase is a selenocysteine-containing enzyme
TL;DR: It is found that the mRNA for this enzyme contains a UGA codon for selenocysteine which is necessary for maximal enzyme activity and explains why conversion of T4 to T3 is impaired in experimental selenium deficiency2–6 and identifies an essential role for this trace element in thyroid hormone action.
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Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation
Leila Yassa,Edmund S. Cibas,Carol B. Benson,Mary C. Frates,Peter M. Doubilet,Atul A. Gawande,Francis D. Moore,Brian W. Kim,Vânia Nosé,Ellen Marqusee,P. Reed Larsen,Erik K. Alexander +11 more
TL;DR: The diagnostic evaluation of patients with thyroid nodules is imprecise, and recent technologic and procedural advances suggest that this shortcoming can be mitigated, although few data confirm this benefit in unselected patients.
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Prevalence and Distribution of Carcinoma in Patients with Solitary and Multiple Thyroid Nodules on Sonography
Mary C. Frates,Carol B. Benson,Peter M. Doubilet,Elizabeth Kunreuther,Maricela Contreras,Edmund S. Cibas,Joseph Orcutt,Francis D. Moore,P. Reed Larsen,Ellen Marqusee,Erik K. Alexander +10 more
TL;DR: In a patient with one or more thyroid nodules larger than 10 mm in diameter, the likelihood of thyroid cancer per patient is independent of the number of nodules, whereas the likelihood per nodule decreases as the numberof nodules increases.