Prevalence and Distribution of Carcinoma in Patients with Solitary and Multiple Thyroid Nodules on Sonography
Mary C. Frates,Carol B. Benson,Peter M. Doubilet,Elizabeth Kunreuther,Maricela Contreras,Edmund S. Cibas,Joseph Orcutt,Francis D. Moore,P. Reed Larsen,Ellen Marqusee,Erik K. Alexander +10 more
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TLDR
In a patient with one or more thyroid nodules larger than 10 mm in diameter, the likelihood of thyroid cancer per patient is independent of the number of nodules, whereas the likelihood per nodule decreases as the numberof nodules increases.Abstract:
Context: Controversy remains as to the optimal management of patients with multiple thyroid nodules. Objective: The objective of this study was to determine the prevalence, distribution, and sonographic features of thyroid cancer in patients with solitary and multiple thyroid nodules. Design: We describe a retrospective observational cohort study that was carried out from 1995 to 2003. Setting: The study was conducted in a tertiary care hospital. Patients: Patients with one or more thyroid nodules larger than 10 mm in diameter who had ultrasound-guided fine needle aspiration (FNA) were included in the study. Main Outcome Measures: The main outcome measures were prevalence and distribution of thyroid cancer and the predictive value of demographic and sonographic features. Results: A total of 1985 patients underwent FNA of 3483 nodules. The prevalence of thyroid cancer was similar between patients with a solitary nodule (175 of 1181 patients, 14.8%) and patients with multiple nodules (120 of 804, 14.9%) (P ...read more
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Journal ArticleDOI
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Bryan R. Haugen,Erik K. Alexander,Keith C. Bible,Gerard M. Doherty,Susan J. Mandel,Yuri E. Nikiforov,Furio Pacini,Gregory W. Randolph,Anna M. Sawka,Martin Schlumberger,Kathryn G. Schuff,Steven I. Sherman,Julie Ann Sosa,David L. Steward,R. Michael Tuttle,Leonard Wartofsky +15 more
TL;DR: Evidence-based recommendations are developed to inform clinical decision-making in the management of thyroid nodules and differentiated thyroid cancer and represent, in the authors' opinion, contemporary optimal care for patients with these disorders.
Journal ArticleDOI
Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer
David S. Cooper,Gerard M. Doherty,Bryan R. Haugen,Richard T. Kloos,Stephanie L. Lee,Susan J. Mandel,Ernest L. Mazzaferri,Bryan McIver,Furio Pacini,Martin Schlumberger,Steven I. Sherman,David L. Steward,R. Michael Tuttle +12 more
TL;DR: Evidence-based recommendations in response to the appointment as an independent task force by the American Thyroid Association to assist in the clinical management of patients with thyroid nodules and differentiated thyroid cancer represent, in the authors' opinion, contemporary optimal care for patients with these disorders.
Journal ArticleDOI
Worldwide increasing incidence of thyroid cancer: Update on epidemiology and risk factors
Gabriella Pellegriti,Francesco Frasca,Concetto Regalbuto,Sebastiano Squatrito,Riccardo Vigneri +4 more
TL;DR: The increased incidence of thyroid cancer is most likely due to a combination of an apparent increase due to more sensitive diagnostic procedures and of a true increase, a possible consequence of increased population exposure to radiation and to other still unrecognized carcinogens.
Journal ArticleDOI
American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association Medical Guidelines for Clinical Practice for the Diagnosis and Management of thyroid Nodules
Hossein Gharib,Enrico Papini,Ralf Paschke,Daniel S. Duick,Roberto Valcavi,Laszlo Hegedüs,Paolo Vitti +6 more
TL;DR: These guidelines are a working document that reflects the state of the field at the time of publication and any decision by practitioners to apply these guidelines must be made in light of local resources and individual patient circumstances.
Journal ArticleDOI
Benign and malignant thyroid nodules: US differentiation--multicenter retrospective study.
Won-Jin Moon,So Lyung Jung,Jeong Hyun Lee,Dong Gyu Na,Jung-Hwan Baek,Young Hen Lee,Jinna Kim,Hyun Sook Kim,Jun Soo Byun,Dong-Hoon Lee +9 more
TL;DR: Shape, margin, echogenicity, and presence of calcification are helpful criteria for the discrimination of malignant from benign nodules; the diagnostic accuracy of US criteria is dependent on tumor size.
References
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Journal ArticleDOI
Management guidelines for patients with thyroid nodules and differentiated thyroid cancer.
Journal ArticleDOI
Clinical practice. The thyroid nodule.
TL;DR: Improvement of existing tests or the addition of new tests for evaluating thyroid nodules will aid in distinguishing between benign and malignant thyroid nodule.
Journal ArticleDOI
Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features.
Enrico Papini,Rinaldo Guglielmi,Antonio Bianchini,Anna Crescenzi,Silvia Taccogna,Francesco Nardi,Claudio Panunzi,R. Rinaldi,Vincenzo Toscano,Claudio Maurizio Pacella +9 more
TL;DR: The aim of the study was to correlate the sonographic and color-Doppler findings with the results of US-guided fine needle aspiration biopsy and of pathologic staging of resected carcinomas to establish the relative importance of US features as risk factors of malignancy and a cost-effective management of nonpalpable thyroid nodules.
Journal ArticleDOI
Management of a Solitary Thyroid Nodule
TL;DR: This review describes a strategy for the treatment of clinically euthyroid patients who have a solitary thyroid nodule that prevents unnecessary testing while identifying the few patients who require therapy.
Journal ArticleDOI
Fine-Needle Aspiration Biopsy of the Thyroid: An Appraisal
Hossein Gharib,John R. Goellner +1 more
TL;DR: The utility and limitations of fine-needle aspiration biopsy in the evaluation and management of thyroid nodules are examined by reviewing studies reported in the literature from 1982 to 1991 and using 12 years of experience with more than 11 000 biopsies to offer a reasoned approach to the management of nodular thyroid disease.
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2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Management of thyroid nodules detected at US: Society of radiologists in ultrasound consensus conference statement
Mary C. Frates,Carol B. Benson,J. William Charboneau,Edmund S. Cibas,Orlo H. Clark,Beverly G. Coleman,John J. Cronan,Peter M. Doubilet,Douglas B. Evans,John R. Goellner,Ian D. Hay,Barbara S. Hertzberg,Charles M. Intenzo,R. Brooke Jeffrey,Jill E. Langer,P. Reed Larsen,Susan J. Mandel,William D. Middleton,Carl C. Reading,Steven I. Sherman,Franklin N. Tessler +20 more