P. Spanne

TL;DR: Adult‐rat‐brain tissues display an unusually high resistance to necrosis when serially irradiated with parallel, thin slices of a microplanar beam of synchrotron‐wiggler‐generated X rays, and correlation with radiation doses shows that loss of tissue structure was confined to beam‐crossing regions and that only minor damage was done to zones of the brain irradiated unidirectionally.

TL;DR: It is proposed to carry out radiotherapy and radiosurgery for brain lesions by crossfiring an array of parallel, closely spaced microbeams of synchrotron-generated x rays several times through an i-modelling system.

TL;DR: No other kind of brain damage was evident histologically in any rat with entrance absorbed doses < or = 5000 Gy, and this unusual resistance to necrosis is central to the rationale of microplanar beam radiation therapy for brain tumors.

TL;DR: Microbeam radiation therapy of the intracerebral 9L gliosarcoma in rats, an experimental surrogate for human malignant gliomas, using mainly 30–130 keV wiggler‐generated x rays, extended the residual lifespans of some rats ten or more times over those of untreated, similar gliosARcoma‐bearing rats.

TL;DR: In this paper, rats were implanted intracerebrally with 9L gliosarcoma cells, and they were used to experimentally determine the curative effectiveness of synchrotron radiation produced by the NSS.