Journal ArticleDOI
Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-wiggler-generated X rays.
Jean A. Laissue,G Geiser,P. Spanne,F.A. Dilmanian,J.-O. Gebbers,Marianne Geiser,X. Y. Wu,Michael S. Makar,Peggy L. Micca,Marta M. Nawrocky,Darrel D. Joel,Daniel N. Slatkin,Daniel N. Slatkin +12 more
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TLDR
Adult‐rat‐brain tissues display an unusually high resistance to necrosis when serially irradiated with parallel, thin slices of a microplanar beam of synchrotron‐wiggler‐generated X rays, and correlation with radiation doses shows that loss of tissue structure was confined to beam‐crossing regions and that only minor damage was done to zones of the brain irradiated unidirectionally.Abstract:
Adult-rat-brain tissues display an unusually high resistance to necrosis when serially irradiated with parallel, thin slices of a microplanar (i.e., microscopically thin and macroscopically broad) beam of synchrotron-wiggler-generated, approx. 35-120 keV (median approx. 50 keV) Gd-filtered X rays at skin-entrance absorbed doses of 312 to 5000 Gy per slice. Such microplanar beams were used to irradiate young adult rats bearing right frontocerebral 9L gliosarcomas (approx. 4 mm diameter), through a volume of tissue containing the tumor and contiguous brain tissue, either in a single array or in 2 orthogonally crossed arrays of tissue slices. Each array included 101 parallel microplanar slices, 100 microm center-to-center distance, each slice being approx. 25 microm wide and 12 mm high, with skin-entrance absorbed doses of 312.5 Gy or 625 Gy per slice. Compared with unirradiated controls with a median survival time of 20 days after tumor initiation, the median survival time was extended in irradiated rats by 139 days (625 Gy, crossed arrays), 96 days (312 Gy, crossed arrays) or 24 days (625 Gy, single array). The tumors disappeared in 22 of the 36 irradiated rats, 4/11 even after unidirectional microbeam irradiation. The extent and severity of radiation damage to the normal brain in rats with or without tumor was graded histopathologically. Correlation of those grades with radiation doses shows that loss of tissue structure was confined to beam-crossing regions and that only minor damage was done to zones of the brain irradiated unidirectionally.read more
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Journal ArticleDOI
Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy.
Wan Nordiana Rahman,Nour B. Bishara,Trevor Ackerly,C. He,C. He,Price Jackson,C Wong,Rob Davidson,Moshi Geso +8 more
TL;DR: In this paper, gold nanoparticles (AuNPs) have been used for the enhancement of radiation effects on bovine aortic endothelial cells of superficial x-ray radiation therapy and megavoltage electron radiation therapy beams.
Gold Nanoparticles: Clinical Nanomedicine, Radiation Oncology Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy
TL;DR: It is shown that AuNPs can be used to enhance the effect of radiation doses from kilovoltage x-ray radiation therapy and megavoltage electron radiation therapy beams, where it has been proven that more of the AuNps injected into animals ends up into the blood than in the tumor.
Journal ArticleDOI
Medical applications of synchrotron radiation.
TL;DR: The medical imaging and therapeutic technologies that are based on the use of radiation are reviewed briefly, with special emphasis on the recent developments of synchrotron radiation (SR) methods.
Journal ArticleDOI
Radiochromic film dosimetry
TL;DR: The strength of radiochromic films is most evident in applications where there is a very high dose gradient and relatively high absorbed dose rates, and at the edges (penumbra regions) of larger fields.
Journal ArticleDOI
Toward an image-guided microbeam radiation therapy using gadolinium-based nanoparticles.
Géraldine Le Duc,Imen Miladi,Christophe Alric,Pierre Mowat,Elke Bräuer-Krisch,Audrey Bouchet,Enam A. Khalil,Claire Billotey,Marc Janier,François Lux,Thierry Epicier,Pascal Perriat,Stéphane Roux,Stéphane Roux,Olivier Tillement +14 more
TL;DR: GBNs exhibit an interesting potential for image-guided radiotherapy since the radiosensitizing effect of GBNs can be activated by X-ray microbeams when the gadolinium content is enough in the tumor and low in the surrounding healthy tissue.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Practical Nonparametric Statistics
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Treatment volume and tissue tolerance
TL;DR: T tentative conclusions were drawn regarding the influence on "tolerance" doses of tissue organization and the volume of an organ irradiated and sigmoid dose response curves, which are sensitive to small increases in "biologically effective" dose.
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