Journal ArticleDOI
Microbeam radiation therapy.
Reads0
Chats0
TLDR
It is proposed to carry out radiotherapy and radiosurgery for brain lesions by crossfiring an array of parallel, closely spaced microbeams of synchrotron-generated x rays several times through an i-modelling system.Abstract:
It is proposed to carry out radiotherapy and radiosurgery for brain lesions by crossfiring an array of parallel, closely spaced microbeams of synchrotron-generated x rays several times through an isocentric target, each microbeam in the array having an approximately 25-microns-wide adjustable-height rectangular cross section. The following inferences from the known tissue sparing of 22-MeV deuteron microbeams in the mouse brain and the following exemplary Monte Carlo computations indicate that endothelial cells in the brain that are lethally irradiated by any microbeam in an array of adequately spaced microbeams outside an isocentric target will be replaced by endothelial cells regenerated from microscopically contiguous, minimally irradiated endothelium in intermicrobeam segments of brain vasculature. Endothelial regeneration will prevent necrosis of the nontargeted parenchymal tissue. However, neoplastic and/or nonneoplastic targeted tissues at the isocenter will be so severely depleted of potentially mitotic endothelial and parenchymal cells by multiple overlapping microbeams that necrosis will ensue. The Monte Carlo computations simulate microbeam irradiations of a 16-cm diameter, 16-cm-long cylindrical human head phantom using 50-, 100-, and 150-keV monochromatic x rays.read more
Citations
More filters
Journal ArticleDOI
Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-wiggler-generated X rays.
Jean A. Laissue,G Geiser,P. Spanne,F.A. Dilmanian,J.-O. Gebbers,Marianne Geiser,X. Y. Wu,Michael S. Makar,Peggy L. Micca,Marta M. Nawrocky,Darrel D. Joel,Daniel N. Slatkin,Daniel N. Slatkin +12 more
TL;DR: Adult‐rat‐brain tissues display an unusually high resistance to necrosis when serially irradiated with parallel, thin slices of a microplanar beam of synchrotron‐wiggler‐generated X rays, and correlation with radiation doses shows that loss of tissue structure was confined to beam‐crossing regions and that only minor damage was done to zones of the brain irradiated unidirectionally.
Journal ArticleDOI
Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy.
F. Avraham Dilmanian,Terry M. Button,Géraldine Le Duc,Nan Zhong,Louis A. Peña,Jennifer A.L. Smith,Steve R. Martinez,Tigran Bacarian,Jennifer Tammam,B. Ren,Peter M. Farmer,John Kalef-Ezra,Peggy L. Micca,Marta M. Nawrocky,James A. Niederer,F. Peter Recksiek,Alexander Fuchs,Eliot M. Rosen +17 more
TL;DR: The results suggest that the therapeutic index of unidirectional microbeams is larger than that of the broad beams and that an application for microbeam radiation therapy in treating certain malignant brain tumors may be found in the future.
Journal ArticleDOI
Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissue.
Elke Bräuer-Krisch,Raphaël Serduc,E.A. Siegbahn,G. Le Duc,Yolanda Prezado,Alberto Bravin,Hans Blattmann,Jean A. Laissue +7 more
TL;DR: The paper highlights the history of MRT including salient biological findings after microbeam irradiation with emphasis on the vascular components and the tolerance of the central nervous system and details on experimental and theoretical dosimetry of microbeams, core issues and possible therapeutic applications of M RT are presented.
Journal ArticleDOI
Interlaced x-ray microplanar beams: a radiosurgery approach with clinical potential.
F. Avraham Dilmanian,Zhong Zhong,Tigran Bacarian,Helene Benveniste,Pantaleo Romanelli,Ruiliang Wang,Jeremy Welwart,Tetsuya Yuasa,Eliot M. Rosen,David J. Anschel +9 more
TL;DR: Potential application of interlaced microbeams to treat tumors or to ablate nontumorous abnormalities with minimal damage to surrounding normal tissue is suggested.
Related Papers (5)
Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy.
Weanling piglet cerebellum: a surrogate for tolerance to MRT (microbeam radiation therapy) in pediatric neuro-oncology
Jean A. Laissue,Hans Blattmann,Marco Di Michiel,Daniel N. Slatkin,N. Lyubimova,R. Guzman,Werner Zimmermann,Stephan Birrer,T. Bley,Patrick R Kircher,Regina Stettler,R. Fatzer,André Jaggy,Henry M. Smilowitz,Elke Brauer,Alberto Bravin,Géraldine Le Duc,Christian Nemoz,Michel Renier,William Thomlinson,Jiri Stepanek,Wagner Hp +21 more