P
Pablo Smircich
Researcher at University of the Republic
Publications - 53
Citations - 934
Pablo Smircich is an academic researcher from University of the Republic. The author has contributed to research in topics: Gene & Trypanosoma cruzi. The author has an hindex of 15, co-authored 47 publications receiving 736 citations.
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Journal ArticleDOI
Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi
Pablo Smircich,Guillermo Eastman,Saloe Bispo,María Ana Duhagon,Eloise P. Guerra-Slompo,Beatriz Garat,Samuel Goldenberg,David J. Munroe,Bruno Dallagiovanna,Fabiola Barbieri Holetz,José R. Sotelo-Silveira +10 more
TL;DR: A large subset of genes is modulated at the translation level in two different stages of Trypanosoma cruzi life cycle, indicating different degrees of control operating to prepare the parasite for an infective life form.
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Genomes of Fasciola hepatica from the Americas reveal colonization with Neorickettsia Endobacteria related to the agents of Potomac Horse and Human Sennetsu Fevers
Samantha N. McNulty,José F. Tort,Gabriel Rinaldi,Kerstin Fischer,Bruce A. Rosa,Pablo Smircich,Santiago Fontenla,Young Jun Choi,Rahul Tyagi,Kymberlie Hallsworth-Pepin,Victoria H. Mann,Lakshmi Kammili,Patricia S. Latham,Nicolás Dell’Oca,Fernanda Dominguez,Carlos Carmona,Peter Fischer,Paul J. Brindley,Makedonka Mitreva +18 more
TL;DR: A reference genome sequence of the common liver fluke, Fasciola hepatica isolated from sheep, is presented, complementing previously reported isolate from cattle and leading to the first discovery of an endobacteria in this species.
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Survey of transcripts expressed by the invasive juvenile stage of the liver fluke Fasciola hepatica
Martín Cancela,Martín Cancela,Natalia Ruétalo,Nicolás Dell’Oca,Edileuza Danieli da Silva,Pablo Smircich,Gabriel Rinaldi,Leda Roche,Carlos Carmona,Fernando Alvarez-Valin,Arnaldo Zaha,José F. Tort +11 more
TL;DR: The knowledge of the genes expressed by the invasive stage of Fasciola hepatica is a starting point to unravel key aspects of this parasite's biology.
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Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an inhibitory effect on parasite-specific fumarate reductase.
Marisol Vieites,Pablo Smircich,Beatriz S. Parajón-Costa,Jorge Rodríguez,Verónica Galaz,Claudio Olea-Azar,Lucía Otero,Gabriela Aguirre,Hugo Cerecetto,Mercedes González,Alicia Gómez-Barrio,Beatriz Garat,Dinorah Gambino +12 more
TL;DR: The data strongly suggest that trypanocidal action of the complexes could mainly rely on the inhibition of the parasite-specific enzyme NADH-fumarate reductase.
Journal ArticleDOI
Synthesis and characterization of a pyridine-2-thiol N-oxide gold(I) complex with potent antiproliferative effect against Trypanosoma cruzi and Leishmania sp. insight into its mechanism of action.
Marisol Vieites,Pablo Smircich,Lucía Guggeri,Edgar Marchán,Alicia Gómez-Barrio,Maribel Navarro,Beatriz Garat,Dinorah Gambino +7 more
TL;DR: Due to its low unspecific cytotoxicity on mammalian cells (J774 macrophages), the new gold complex showed a selective anti-parasite activity and constitutes a promising new potent chemotherapeutic alternative to be evaluated in vivo in experimental models of leishmaniasis and Chagas disease.