P
Pallavi Chaturvedi
Researcher at Johns Hopkins University
Publications - 40
Citations - 4229
Pallavi Chaturvedi is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Metastasis & Biology. The author has an hindex of 20, co-authored 24 publications receiving 3587 citations. Previous affiliations of Pallavi Chaturvedi include University of Nebraska Medical Center & Johns Hopkins University School of Medicine.
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Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
TL;DR: Results demonstrate that HIF expression and transcriptional activity are induced by treatment of MDA-MB-231, SUM-149, and SUM-159, which are human TNBC cell lines, as well as MCF-7, which is an ER+/PR+ breast cancer line, with paclitaxel or gemcitabine.
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Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts
TL;DR: It is demonstrated that hypoxia-inducible factor 1 (HIF-1) is a critical regulator of ECM remodeling by fibroblasts under hypoxic conditions, which induces changes in breast cancer cell morphology, adhesion, and motility that promote invasion and metastasis.
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Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
Ting Wang,Daniele M. Gilkes,Naoharu Takano,Lisha Xiang,Weibo Luo,Corey J. Bishop,Pallavi Chaturvedi,Jordan J. Green,Gregg L. Semenza +8 more
TL;DR: Exposure of human breast cancer cells to hypoxia augments MV shedding that is mediated by the HIF-dependent expression of the small GTPase RAB22A, which colocalizes with budding MVs at the cell surface.
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Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
Carmen Chak-Lui Wong,Daniele M. Gilkes,Huafeng Zhang,Huafeng Zhang,Jasper Chen,Hong Wei,Pallavi Chaturvedi,Stephanie I. Fraley,Chun-Ming Wong,Ui-Soon Khoo,Irene Oi-Lin Ng,Denis Wirtz,Gregg L. Semenza +12 more
TL;DR: It is demonstrated that hypoxia-inducible factor 1 (HIF-1) is a critical regulator of breast cancer metastatic niche formation through induction of multiple members of the lysyl oxidase (LOX) family, including LOX, LOX-like 2, and LOx-like 4, which catalyze collagen cross-linking in the lungs before BMDC recruitment.
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HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
Huafeng Zhang,Huafeng Zhang,Carmen Chak-Lui Wong,Hong Wei,Daniele M. Gilkes,Preethi Korangath,Pallavi Chaturvedi,Luana Schito,Luana Schito,Jasper Chen,Balaji Krishnamachary,Paul T. Winnard,Venu Raman,L. Zhen,W. A. Mitzner,Saraswati Sukumar,Gregg L. Semenza +16 more
TL;DR: It is demonstrated that inhibition of hypoxia-inducible factor activity in BrCa cells by RNA interference or digoxin treatment inhibits primary tumor growth and also inhibits the metastasis of Br Ca cells to the lungs by blocking the expression of angiopoietin-like 4 (ANGPTL4) and L1 cell adhesion molecule (L1CAM).