D
Daniele M. Gilkes
Researcher at Johns Hopkins University
Publications - 77
Citations - 8374
Daniele M. Gilkes is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Breast cancer & Metastasis. The author has an hindex of 41, co-authored 66 publications receiving 6672 citations. Previous affiliations of Daniele M. Gilkes include Johns Hopkins University School of Medicine & University of South Florida.
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Hypoxia and the extracellular matrix: drivers of tumour metastasis
TL;DR: A direct link between hypoxia and the composition and the organization of the ECM is established, which suggests a new model in which multiple microenvironmental signals might converge to synergistically influence metastatic outcome.
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Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
TL;DR: Results demonstrate that HIF expression and transcriptional activity are induced by treatment of MDA-MB-231, SUM-149, and SUM-159, which are human TNBC cell lines, as well as MCF-7, which is an ER+/PR+ breast cancer line, with paclitaxel or gemcitabine.
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Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts
TL;DR: It is demonstrated that hypoxia-inducible factor 1 (HIF-1) is a critical regulator of ECM remodeling by fibroblasts under hypoxic conditions, which induces changes in breast cancer cell morphology, adhesion, and motility that promote invasion and metastasis.
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Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
Ting Wang,Daniele M. Gilkes,Naoharu Takano,Lisha Xiang,Weibo Luo,Corey J. Bishop,Pallavi Chaturvedi,Jordan J. Green,Gregg L. Semenza +8 more
TL;DR: Exposure of human breast cancer cells to hypoxia augments MV shedding that is mediated by the HIF-dependent expression of the small GTPase RAB22A, which colocalizes with budding MVs at the cell surface.
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Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
Carmen Chak-Lui Wong,Daniele M. Gilkes,Huafeng Zhang,Huafeng Zhang,Jasper Chen,Hong Wei,Pallavi Chaturvedi,Stephanie I. Fraley,Chun-Ming Wong,Ui-Soon Khoo,Irene Oi-Lin Ng,Denis Wirtz,Gregg L. Semenza +12 more
TL;DR: It is demonstrated that hypoxia-inducible factor 1 (HIF-1) is a critical regulator of breast cancer metastatic niche formation through induction of multiple members of the lysyl oxidase (LOX) family, including LOX, LOX-like 2, and LOx-like 4, which catalyze collagen cross-linking in the lungs before BMDC recruitment.