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Pamela J. Ovendale
Researcher at Corixa Corporation
Publications - 16
Citations - 1312
Pamela J. Ovendale is an academic researcher from Corixa Corporation. The author has contributed to research in topics: Mycobacterium tuberculosis & Antigen. The author has an hindex of 15, co-authored 16 publications receiving 1281 citations.
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Journal ArticleDOI
Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein.
Yasir A. W. Skeiky,Mark R. Alderson,Pamela J. Ovendale,Jeffrey A. Guderian,Lise Brandt,Davin C. Dillon,Antonio Campos-Neto,Yves Lobet,Wilfried Dalemans,Ian M. Orme,Steven G. Reed,Steven G. Reed +11 more
TL;DR: All three forms of Mtb72F immunization resulted in the protection of C57BL/6 mice against aerosol challenge with a virulent strain of M. tuberculosis comparable to bacillus Calmette-Guérin immunization.
Journal ArticleDOI
Human and Murine Immune Responses to a Novel Leishmania major Recombinant Protein Encoded by Members of a Multicopy Gene Family
John R. Webb,Antonio Campos-Neto,Pamela J. Ovendale,Tricia I. Martin,Erika Jean Stromberg,Roberto Badaró,Steven G. Reed,Steven G. Reed,Steven G. Reed +8 more
TL;DR: Immunization of BALB/c mice with recombinant TSA protein resulted in the development of strong cellular immune responses and conferred protective immune responses against infection with L. major, suggesting that the TSA protein may be useful as a component of a subunit vaccine against leishmaniasis.
Journal Article
LeIF: A Recombinant Leishmania Protein That Induces an IL-12-Mediated Th1 Cytokine Profile
Yasir A. W. Skeiky,Mary K. Kennedy,David R. Kaufman,Monamaris M. Borges,Jeffrey A. Guderian,Scholler John,Pamela J. Ovendale,Kathleen S. Picha,Philip J. Morrissey,Kenneth H. Grabstein,Antonio Campos-Neto,Steven G. Reed +11 more
TL;DR: The results suggest the potential of LeIF as a Th1-type adjuvant and as a therapeutic and prophylactic vaccine Ag for leish maniasis when used with other leishmanial Ags.
Journal ArticleDOI
T Cell Expression Cloning of a Mycobacterium tuberculosis Gene Encoding a Protective Antigen Associated with the Early Control of Infection
Yasir A. W. Skeiky,Pamela J. Ovendale,Shyian Jen,Mark R. Alderson,Davin C. Dillon,Sherilyn Smith,Chris Wilson,Ian M. Orme,Steven G. Reed,Steven G. Reed,Steven G. Reed,Antonio Campos-Neto +11 more
TL;DR: The use of a proven protective T cell line in conjunction with direct T cell expression cloning approach resulted in the identification of a candidate Ag for a subunit vaccine against tuberculosis.
Journal ArticleDOI
Vaccination with the T Cell Antigen Mtb 8.4 Protects Against Challenge with Mycobacterium tuberculosis
Rhea N. Coler,Antonio Campos-Neto,Pamela J. Ovendale,Fiona H. Day,Steven P. Fling,Liqing Zhu,Natalya V. Serbina,JoAnne L. Flynn,Steven G. Reed,Steven G. Reed,Mark R. Alderson +10 more
TL;DR: It is reported that Mtb 8.4-specific T cells can be detected in mice immunized with the current live attenuated vaccine, Mycobacterium bovis-bacillus Calmette-Guérin, and in mice infected i.v. with M. tuberculosis.