M
Mark R. Alderson
Researcher at PATH
Publications - 84
Citations - 7591
Mark R. Alderson is an academic researcher from PATH. The author has contributed to research in topics: Antigen & T cell. The author has an hindex of 45, co-authored 82 publications receiving 7236 citations. Previous affiliations of Mark R. Alderson include Amgen & Infectious Disease Research Institute.
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Journal ArticleDOI
Fas ligand mediates activation-induced cell death in human T lymphocytes.
Mark R. Alderson,T W Tough,T Davis-Smith,S Braddy,Ben A. Falk,K A Schooley,Raymond G. Goodwin,Craig A. Smith,Fred Ramsdell,David H. Lynch +9 more
TL;DR: In this article, a significant proportion of previously activated human T cells undergo apoptosis when triggered through the CD3/T cell receptor complex, a process termed activation-induced cell death (AICD).
Journal ArticleDOI
Interleukin 1 signaling occurs exclusively via the type I receptor.
John E. Sims,M A Gayle,Jennifer L. Slack,Mark R. Alderson,T A Bird,J G Giri,Francesco Colotta,Fabio Re,Alberto Mantovani,K Shanebeck +9 more
TL;DR: It is concluded that a very small number of type I receptors is sufficient to mediate all of the actions of IL-1 which are examined here and that the function of the type II receptor may not be to transduce signals.
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CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40.
TL;DR: In this article, CD40 ligand-transfected cells provided a potent costimulus for monocyte TNF-alpha and IL-6 production in the presence of granulocyte/macrophage colony-stimulating factor (GM-CSF), IL-3, or IFN-gamma.
Journal ArticleDOI
Fas transduces activation signals in normal human T lymphocytes.
Mark R. Alderson,R J Armitage,Eugene Maraskovsky,T W Tough,E Roux,K A Schooley,Fred Ramsdell,David H. Lynch +7 more
TL;DR: The data demonstrate that in addition to a role in the induction of apoptosis in certain transformed cell lines, the Fas protein may also play an important role inThe activation and proliferation of normal T cells.
Journal ArticleDOI
Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein.
Yasir A. W. Skeiky,Mark R. Alderson,Pamela J. Ovendale,Jeffrey A. Guderian,Lise Brandt,Davin C. Dillon,Antonio Campos-Neto,Yves Lobet,Wilfried Dalemans,Ian M. Orme,Steven G. Reed,Steven G. Reed +11 more
TL;DR: All three forms of Mtb72F immunization resulted in the protection of C57BL/6 mice against aerosol challenge with a virulent strain of M. tuberculosis comparable to bacillus Calmette-Guérin immunization.