P
Pamela Staker
Researcher at National Institutes of Health
Publications - 5
Citations - 924
Pamela Staker is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Hepcidin & Thalassemia. The author has an hindex of 3, co-authored 5 publications receiving 862 citations.
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Journal ArticleDOI
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin.
Toshihiko Tanno,Natarajan V. Bhanu,Patricia A. Oneal,Sung-Ho Goh,Pamela Staker,Y. Terry Lee,John W. Moroney,Christopher H. Reed,Naomi L.C. Luban,Rui-Hong Wang,Thomas E. Eling,Richard W. Childs,Tomas Ganz,Susan F. Leitman,Suthat Fucharoen,Jeffery L. Miller +15 more
TL;DR: It is suggested that GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.
Journal ArticleDOI
RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals
Kong Y. Chen,Ranganath Muniyappa,Brent S. Abel,Katherine P. Mullins,Pamela Staker,Robert J. Brychta,Xiongce Zhao,Michael Ring,Tricia L. Psota,Roger D. Cone,Brandon L. Panaro,Keith Gottesdiener,Lex H.T. Van der Ploeg,Marc L. Reitman,Monica C. Skarulis +14 more
TL;DR: Short-term administration of the MC4R agonist RM-493 increases REE and shifts substrate oxidation to fat in obese individuals and no adverse effect on heart rate or blood pressure was observed.
Journal ArticleDOI
Discovery of Growth Differentiation Factor 15 as an Erythroblast-Secreted Regulator of Hepcidin with Very High Level Expression in Patients with Thalassemia.
Toshihiko Tanno,Natarajan V. Bhanu,Patricia A. Oneal,Sung-Ho Goh,Pamela Staker,Y. Terry Lee,Naomi L.C. Luban,Richard W. Childs,Susan F. Leitman,Jeffery L. Miller +9 more
TL;DR: The novel findings suggest that GDF15 is secreted from human erythroblasts, released into the circulation at extremely high levels in thalassemia patients, and contributes to iron overloading in those patients by suppressing hepcidin expression.
Journal ArticleDOI
Genomic Composition of Howell-Jolly Bodies.
Nicole M. Gantt,Bob Walker,Y. Terry Lee,Yuan Jiang,Pamela Staker,Patricia A. Oneal,Natarajan V. Bhanu,Paul S. Meltzer,Jeffery L. Miller +8 more
TL;DR: Data suggest Howell-Jolly Bodies contain a non-random distribution of centromere-depleted chromatin generated after DNA double-strand breakage during erythroid differentiation.
Journal ArticleDOI
Twisted Gastrulation (TWSG1) Is Expressed at Elevated Levels in Thalassemia and Regulates Bone Morphogenic Protein Signaling.
Toshihiko Tanno,Prashanth Porayette,Ajoy Bhupatiraju,Pamela Staker,Y. Terry Lee,Suthat Fucharoen,Robert F. Paulson,Jeffery L. Miller +7 more
TL;DR: In this article, the authors used transcriptome screens of erythroblasts to identify twisted gastrulation (TWSG1) as a second candidate protein for further study and found that splenic expression levels of Tsg (murine TWSG1) were significantly higher in thalassemia mice.