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Naomi L.C. Luban
Researcher at George Washington University
Publications - 180
Citations - 7556
Naomi L.C. Luban is an academic researcher from George Washington University. The author has contributed to research in topics: Population & Anemia. The author has an hindex of 42, co-authored 178 publications receiving 6898 citations. Previous affiliations of Naomi L.C. Luban include Boston Children's Hospital & University of Pittsburgh.
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Journal ArticleDOI
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin.
Toshihiko Tanno,Natarajan V. Bhanu,Patricia A. Oneal,Sung-Ho Goh,Pamela Staker,Y. Terry Lee,John W. Moroney,Christopher H. Reed,Naomi L.C. Luban,Rui-Hong Wang,Thomas E. Eling,Richard W. Childs,Tomas Ganz,Susan F. Leitman,Suthat Fucharoen,Jeffery L. Miller +15 more
TL;DR: It is suggested that GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.
Journal ArticleDOI
Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia - TCD with Transfusions Changing to Hydroxyurea (TWiTCH): A multicentre, open-label, phase 3, non-inferiority trial
Russell E. Ware,Barry R. Davis,William H. Schultz,R. Clark Brown,Banu Aygun,Sharada A. Sarnaik,Isaac Odame,Beng Fuh,Alex George,William Owen,Lori Luchtman-Jones,Zora R. Rogers,Lee Hilliard,Cynthia Gauger,Connie M. Piccone,Margaret T. Lee,Janet L. Kwiatkowski,Sherron M. Jackson,Scott T. Miller,Carla W. Roberts,Matthew M. Heeney,Theodosia A. Kalfa,Stephen C. Nelson,Hamayun Imran,Kerri Nottage,Ofelia A. Alvarez,Melissa Rhodes,Alexis A. Thompson,Jennifer A. Rothman,Kathleen J. Helton,Donna R. Roberts,Jamie L. Coleman,Melanie J. Bonner,Abdullah Kutlar,Niren Patel,John C. Wood,Linda B. Piller,Peng Wei,Judy Luden,Nicole A. Mortier,Susan E. Stuber,Naomi L.C. Luban,Alan R. Cohen,Sara L. Pressel,Robert J. Adams +44 more
TL;DR: High-risk children with sickle cell anaemia and abnormal TCD velocities who have received at least 1 year of transfusions, and have no MRA-defined severe vasculopathy, hydroxycarbamide treatment can substitute for chronic transfusions to maintain TCD velocity and help to prevent primary stroke.
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Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study
Thomas R. O'Brien,William A. Blattner,David D. Waters,M. Elaine Eyster,Margaret W. Hilgartner,Alan R. Cohen,Naomi L.C. Luban,Angelos Hatzakis,Louis M. Aledort,Philip S. Rosenberg,Wendell J. Miley,Barbara Kroner,James J. Goedert +12 more
TL;DR: The HIV- 1 RNA level during early chronic HIV-1 infection is a strong, age-independent predictor of clinical outcome; low levels define persons with a high probability of long-term AIDS-free survival.
Journal ArticleDOI
Prospective RBC phenotype matching in a stroke-prevention trial in sickle cell anemia: a multicenter transfusion trial.
Elliott Vichinsky,Naomi L.C. Luban,Elizabeth C. Wright,Nancy F. Olivieri,Catherine Driscoll,Charles H. Pegelow,Robert J. Adams +6 more
TL;DR: The purpose of this study was to determine if a multicenter trial could implement a transfusion program utilizing phenotypically matched blood to reduce alloimmunization.
Journal ArticleDOI
Evidence-based practice guidelines for plasma transfusion
John D. Roback,Stephen Caldwell,Jeffrey L. Carson,Robertson D. Davenport,Mary Jo Drew,Anne F. Eder,Mark K. Fung,Marilyn Hamilton,John R. Hess,Naomi L.C. Luban,Jeremy G. Perkins,Bruce S. Sachais,Aryeh Shander,Toby A. Silverman,Ed Snyder,Christopher A. Tormey,John Waters,Ben Djulbegovic +17 more
TL;DR: There is little systematically derived evidence‐based guidance to inform plasma transfusion decisions, so the development of clinical practice guidelines to help direct appropriate transfusion of plasma is commissioned.