P
Patricia A. Oneal
Researcher at National Institutes of Health
Publications - 11
Citations - 953
Patricia A. Oneal is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Globin & Fetal hemoglobin. The author has an hindex of 5, co-authored 11 publications receiving 902 citations. Previous affiliations of Patricia A. Oneal include Children's National Medical Center.
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Journal ArticleDOI
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin.
Toshihiko Tanno,Natarajan V. Bhanu,Patricia A. Oneal,Sung-Ho Goh,Pamela Staker,Y. Terry Lee,John W. Moroney,Christopher H. Reed,Naomi L.C. Luban,Rui-Hong Wang,Thomas E. Eling,Richard W. Childs,Tomas Ganz,Susan F. Leitman,Suthat Fucharoen,Jeffery L. Miller +15 more
TL;DR: It is suggested that GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.
Journal ArticleDOI
Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming.
Orapan Sripichai,Christine M. Kiefer,Natarajan V. Bhanu,Toshihiko Tanno,Seung-Jae Noh,Sung-Ho Goh,J. Eric Russell,Cheryl L. Rognerud,Ching-Nan Ou,Patricia A. Oneal,Emily Riehm Meier,Nicole M. Gantt,Colleen Byrnes,Y. Terry Lee,Ann Dean,Jeffery L. Miller +15 more
TL;DR: Cycline-mediated signal transduction in adult erythroid cells causes significant changes in the pattern of globin gene and protein expression that are associated with distinct histone modifications as well as nuclear reprogramming of erythyroid transcription factors.
Journal ArticleDOI
A sustained and pancellular reversal of gamma-globin gene silencing in adult human erythroid precursor cells.
Natarajan V. Bhanu,Tiffany A. Trice,Y. Terry Lee,Nicole M. Gantt,Patricia A. Oneal,Joseph D. Schwartz,Pierre Noel,Jeffery L. Miller +7 more
TL;DR: A robust and pancellular reversal of gamma-globin gene silencing among hemoglobinized erythroblasts from adult humans may be achieved in the absence of hereditary mutation or direct genomic manipulation.
Journal ArticleDOI
Fetal hemoglobin silencing in humans.
Patricia A. Oneal,Patricia A. Oneal,Nicole M. Gantt,Nicole M. Gantt,Joseph D. Schwartz,Joseph D. Schwartz,Natarajan V. Bhanu,Natarajan V. Bhanu,Y. Terry Lee,Y. Terry Lee,John W. Moroney,John W. Moroney,Christopher H. Reed,Christopher H. Reed,Alan N. Schechter,Alan N. Schechter,Naomi L. C. Luban,Naomi L. C. Luban,Jeffery L. Miller,Jeffery L. Miller +19 more
TL;DR: Age-related changes in globin phenotypes of circulating human erythroid cells were examined and resulted in a novel silencing pattern that is consistent with a "switching" model in humans that initially results largely from gamma- and beta-globin gene coexpression and competition during fetal development.
Journal ArticleDOI
Imatinib-responsive hypereosinophilia in a patient with B cell ALL.
Jamie Robyn,Pierre Noel,Iwona Wlodarska,Mamta Choksi,Patricia A. Oneal,Diane C. Arthur,Cynthia E. Dunbar,Thomas B. Nutman,Amy D. Klion +8 more
TL;DR: This case underscores the importance of follow-up bone marrow examination in patients who demonstrate imatinib mesylate-responsive eosinophilia, and shows a diffuse infiltrate of myeloperoxidase-negative blasts.