P
Pan Sun
Researcher at Shanghai Jiao Tong University
Publications - 6
Citations - 488
Pan Sun is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Phosphorylation & Gene knockdown. The author has an hindex of 4, co-authored 4 publications receiving 388 citations.
Papers
More filters
Journal ArticleDOI
Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Daoxiang Zhang,Daoxiang Zhang,Yongbin Wang,Zhimin Shi,Jingyi Liu,Pan Sun,Xiaodan Hou,Jian Zhang,Shimin Zhao,Binhua P. Zhou,Jun Mi +10 more
TL;DR: It is reported that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis, and downregulation of isocitrate dehydrogenase 3α (IDH3α) is identified as a marker for this switch.
Journal ArticleDOI
MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation
Qiong Li,Daoxiang Zhang,Yongbin Wang,Pan Sun,Xiaodan Hou,James M. Larner,Wujun Xiong,Jun Mi,Jun Mi +8 more
TL;DR: It is demonstrated that miR-21 and Smad7 are critical regulators of TGF-β1 signaling during the induction of CAF formation.
Journal ArticleDOI
Hexokinase 2 regulates G1/S checkpoint through CDK2 in cancer-associated fibroblasts
TL;DR: HK2 regulated the protein level and T14 phosphorylation of CDK2, and knockdown of HK2 resulted in a G1 phase cell cycle arrest, suggesting that HK2 plays important roles in glycolysis regulation and in cell cycle checkpoint activation.
Journal ArticleDOI
miR-186 Regulates Glycolysis through Glut1 During the Formation of Cancer-associated Fibroblasts
TL;DR: Quantitative PCR analysises show miR-186 is downregulated during the CAF formation, and it is demonstrated that the protein and mRNA levels of Glut1 increase during CAf formation, according to Western blot and quantitative PCR analyses, respectively, which suggest that mi R-186 plays important roles in glycolysis regulation as well as cell cycle checkpoint activation.
Journal ArticleDOI
The KIR2DL2/HLA-C1C1 Gene Pairing Is Associated With an Increased Risk of SARS-CoV-2 Infection
Song Hu,Zuoyu Shao,Wei Ni,Pan Sun,Jialu Qiao,Hexing Wan,Yi Huang,Xiaolong Liu,Haoyang Zhai,Mingzhong Xiao,Binlian Sun +10 more
TL;DR: The results suggest that the protective effect of KIR2DL3 against SARS-CoV-2 infection is related to the absence of the KIR1DL2 gene, and that the Kir2DL2/HLA-C1C1 gene pairing may be a risk factor for SARS.