Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Daoxiang Zhang,Daoxiang Zhang,Yongbin Wang,Zhimin Shi,Jingyi Liu,Pan Sun,Xiaodan Hou,Jian Zhang,Shimin Zhao,Binhua P. Zhou,Jun Mi +10 more
TLDR
It is reported that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis, and downregulation of isocitrate dehydrogenase 3α (IDH3α) is identified as a marker for this switch.About:
This article is published in Cell Reports.The article was published on 2015-03-03 and is currently open access. It has received 249 citations till now. The article focuses on the topics: Anaerobic glycolysis & Oxidative phosphorylation.read more
Citations
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The biology and function of fibroblasts in cancer
TL;DR: Cancer-associated fibroblasts (CAFs) become synthetic machines that produce many different tumour components and have a role in creating extracellular matrix structure and metabolic and immune reprogramming of the tumour microenvironment with an impact on adaptive resistance to chemotherapy.
Journal ArticleDOI
Cancer metabolism: a therapeutic perspective
Ubaldo E. Martinez-Outschoorn,Maria Peiris-Pagès,Richard G. Pestell,Federica Sotgia,Federica Sotgia,Michael P. Lisanti +5 more
TL;DR: How cancer cells reprogramme their metabolism and that of other cells within the tumour microenvironment in order to survive and propagate, thus driving disease progression is discussed; in particular, potential metabolic vulnerabilities that might be targeted therapeutically are highlighted.
Journal ArticleDOI
The hypoxic tumour microenvironment.
TL;DR: The most relevant findings describing the influence of hypoxia and the contribution of HIF activation on the major components of the tumour microenvironment are reviewed, and their role in cancer development and progression is summarised.
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Metabolic Interactions in the Tumor Microenvironment
TL;DR: The focus of this review is on the remodeling of the tumor microenvironment that leads to pathophysiologic interactions that are influenced and shaped by metabolism.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
Journal ArticleDOI
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
Journal ArticleDOI
Basement membranes: structure, assembly and role in tumour angiogenesis
TL;DR: The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.
Journal ArticleDOI
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Aria F. Olumi,Gary D. Grossfeld,Simon W. Hayward,Peter R. Carroll,Thea D. Tlsty,Gerald R. Cunha +5 more
TL;DR: In this paper, the authors demonstrate that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in vitro coculture system.
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