P
Paola Borghi
Researcher at Istituto Superiore di Sanità
Publications - 37
Citations - 2308
Paola Borghi is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Interferon & Virus. The author has an hindex of 22, co-authored 37 publications receiving 2201 citations. Previous affiliations of Paola Borghi include National Institutes of Health & Sapienza University of Rome.
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Journal ArticleDOI
ICSBP Is Essential for the Development of Mouse Type I Interferon-producing Cells and for the Generation and Activation of CD8α+ Dendritic Cells
Giovanna Schiavoni,Fabrizio Mattei,Paola Sestili,Paola Borghi,Massimo Venditti,Herbert C. Morse,Filippo Belardelli,Lucia Gabriele +7 more
TL;DR: ICSBP is a crucial factor in the regulation of two possibly linked processes: (a) the development and activity of mIPCs, whose lack in ICSBP−/− mice may explain their high susceptibility to virus infections; (b) the generation and activation of CD8α+ DCs, whose impairment in ICD mice can be responsible for the defective generation of a Th1 type of immune response.
Journal Article
IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages.
Patrizia Puddu,Laura Fantuzzi,Paola Borghi,Barbara Varano,Gabriella Rainaldi,E Guillemard,Walter Malorni,P Nicaise,S F Wolf,Filippo Belardelli,Sandra Gessani +10 more
TL;DR: It is demonstrated that IL-12 can directly stimulate mouse PM to produce IFN-gamma, which is likely to play some role in the generation of the antiviral and immunoregulatory effects of IL- 12.
Journal ArticleDOI
The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8.
Prafullakumar Tailor,Tomohiko Tamura,Hee Jeong Kong,Toru Kubota,Mayumi Kubota,Paola Borghi,Lucia Gabriele,Keiko Ozato +7 more
TL;DR: Data indicate that IRF8 magnifies the second phase of IFN transcription in DCs by prolonging binding of basic transcription machinery to the IFN promoters, thereby playing a role in innate immunity.
Journal ArticleDOI
Loss of CCR2 Expression and Functional Response to Monocyte Chemotactic Protein (MCP-1) During the Differentiation of Human Monocytes: Role of Secreted MCP-1 in the Regulation of the Chemotactic Response
Laura Fantuzzi,Paola Borghi,Veniero Ciolli,George Pavlakis,Filippo Belardelli,Sandra Gessani +5 more
TL;DR: The loss of CCR2 expression and the parallel increase of MCP-1 secretion triggered by differentiation may represent a feedback mechanism in the regulation of the chemotactic response of monocytes/macrophages.
Journal Article
Enhanced production of LPS-induced cytokines during differentiation of human monocytes to macrophages. Role of LPS receptors.
Sandra Gessani,Ugo Testa,Barbara Varano,P Di Marzio,Paola Borghi,Lucia Conti,T. Barberi,Elena Tritarelli,R Martucci,Davide Seripa +9 more
TL;DR: In vitro differentiation of human monocytes to macrophages leads to an enhanced LPS response in terms of a progressive increase of IL-6/TNF-alpha production and an IFN-beta mediated antiviral state, which is not linked to any increased accumulation of cytokine mRNA, but is probably a result of an increased synthesis and/or secretion of these cytokines.