P
Paola Martinelli
Researcher at European Institute of Oncology
Publications - 9
Citations - 654
Paola Martinelli is an academic researcher from European Institute of Oncology. The author has contributed to research in topics: Pancreatic cancer & Carcinogenesis. The author has an hindex of 6, co-authored 9 publications receiving 606 citations. Previous affiliations of Paola Martinelli include Pompeu Fabra University.
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Journal ArticleDOI
Nucleophosmin Is Required for DNA Integrity and p19Arf Protein Stability
Emanuela Colombo,Paola Bonetti,Eros Lazzerini Denchi,Paola Martinelli,Raffaella Zamponi,Jean-Christophe Marine,Kristian Helin,Brunangelo Falini,Pier Giuseppe Pelicci,Pier Giuseppe Pelicci +9 more
TL;DR: It is demonstrated that NPM regulates DNA integrity and, through Arf, inhibits cell proliferation and are consistent with a putative tumor-suppressive function of NPM.
Journal ArticleDOI
Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant.
Emanuela Colombo,Paola Martinelli,Raffaella Zamponi,D. Shing,Paola Bonetti,Lucilla Luzi,Sara Volorio,Loris Bernard,Giancarlo Pruneri,Myriam Alcalay,Pier Giuseppe Pelicci +10 more
TL;DR: It is reported here that the AML-associated NPM mutant localizes mainly in the cy toplasm due to an alteration of its nucleus-cytoplasmic shuttling equilibrium, forms a direct complex with p19(Arf), but is unable to protect it from degradation.
Journal ArticleDOI
NOTCH pathway inactivation promotes bladder cancer progression
Antonio Maraver,Pablo J. Fernandez-Marcos,Timothy P. Cash,Marinela Méndez-Pertuz,Marta Dueñas,Paolo Maietta,Paola Martinelli,Maribel Muñoz-Martin,Mónica Martínez-Fernández,Marta Cañamero,Giovanna Roncador,Jorge L. Martínez-Torrecuadrada,Dimitrios Grivas,José Luis de la Pompa,Alfonso Valencia,Jesús M. Paramio,Francisco X. Real,Manuel Serrano +17 more
TL;DR: Using bladder cancer cells, it is determined that the NOTCH pathway stabilizes the epithelial phenotype through its effector HES1 and, consequently, loss of NOTCH activity favors the process of epithelial-mesenchymal transition.
Journal ArticleDOI
GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1.
Yi Zhong,Zheng Wang,Zheng Wang,Baojin Fu,Fan Pan,Shinichi Yachida,Mousumi Dhara,Emilia Albesiano,Li Li,Li Li,Yoshiki Naito,Felip Vilardell,Felip Vilardell,Christopher T. Cummings,Christopher T. Cummings,Paola Martinelli,Ang Li,Raluca Yonescu,Qingyong Ma,Constance A. Griffin,Francisco X. Real,Christine A. Iacobuzio-Donahue +21 more
TL;DR: It is shown that GATA6 contributes to pancreatic carcinogenesis during the temporal progression of pancreatic intraepithelial neoplasia by virtue of Wnt pathway activation.
Journal ArticleDOI
Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signal
Angela Rosa Mariano,Emanuela Colombo,Lucilla Luzi,Paola Martinelli,Sara Volorio,Loris Bernard,Natalia Meani,Roberta Bergomas,Myriam Alcalay,Pier Giuseppe Pelicci,Pier Giuseppe Pelicci +10 more
TL;DR: It appears that AMLs are frequently characterized by gain-of-function mutations of NPM that create functional NES, suggesting that alterations of nuclear export might represent a general mechanism of leukemogenesis and a novel target for therapeutic intervention.