M
Mousumi Dhara
Researcher at Johns Hopkins University
Publications - 3
Citations - 3027
Mousumi Dhara is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Pancreatic cancer & Promoter. The author has an hindex of 3, co-authored 3 publications receiving 2747 citations.
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Journal ArticleDOI
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
Journal ArticleDOI
Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer
Ian M. Smith,Chad A. Glazer,Suhail K. Mithani,Michael F. Ochs,Wenyue Sun,Sheetal Bhan,Alexander A. Vostrov,Ziedulla Abdullaev,Victor V. Lobanenkov,Andrew Gray,Chunyan Liu,Steven S. Chang,Kimberly Laskie Ostrow,William H. Westra,Shahnaz Begum,Mousumi Dhara,Joseph A. Califano,Joseph A. Califano +17 more
TL;DR: Coordinated, epigenetic unmasking of multiple genes with growth promoting activity occurs in aerodigestive cancers, and BORIS is implicated in the coordinated promoter demethylation and reactivation of epigenetically silenced genes in human cancers.
Journal ArticleDOI
GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1.
Yi Zhong,Zheng Wang,Zheng Wang,Baojin Fu,Fan Pan,Shinichi Yachida,Mousumi Dhara,Emilia Albesiano,Li Li,Li Li,Yoshiki Naito,Felip Vilardell,Felip Vilardell,Christopher T. Cummings,Christopher T. Cummings,Paola Martinelli,Ang Li,Raluca Yonescu,Qingyong Ma,Constance A. Griffin,Francisco X. Real,Christine A. Iacobuzio-Donahue +21 more
TL;DR: It is shown that GATA6 contributes to pancreatic carcinogenesis during the temporal progression of pancreatic intraepithelial neoplasia by virtue of Wnt pathway activation.