M
Myriam Alcalay
Researcher at University of Milan
Publications - 96
Citations - 9144
Myriam Alcalay is an academic researcher from University of Milan. The author has contributed to research in topics: Acute promyelocytic leukemia & Promyelocytic leukemia protein. The author has an hindex of 44, co-authored 92 publications receiving 8630 citations. Previous affiliations of Myriam Alcalay include Sapienza University of Rome & French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype
Brunangelo Falini,Christina Mecucci,Enrico Tiacci,Myriam Alcalay,Roberto Rosati,Laura Pasqualucci,Roberta La Starza,Daniela Diverio,Emanuela Colombo,Antonella Santucci,Barbara Bigerna,Roberta Pacini,Alessandra Pucciarini,Arcangelo Liso,Marco Vignetti,Paola Fazi,Natalia Meani,Valentina Pettirossi,Giuseppe Saglio,Franco Mandelli,Francesco Lo-Coco,Pier Giuseppe Pelicci,Massimo F. Martelli +22 more
TL;DR: Cytoplasmic NPM is a characteristic feature of a large subgroup of patients with AML who have a normal karyotype, NPM gene mutations, and responsiveness to induction chemotherapy.
Journal ArticleDOI
The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells
Francesco Grignani,Pier Francesco Ferrucci,Ugo Testa,Giampaolo Talamo,Marta Fagioli,Myriam Alcalay,Amedea Mencarelli,Fausto Grignani,Cesare Peschle,Cesare Peschle,Ildo Nicoletti,Pier Giuseppe Pelicci +11 more
TL;DR: Expressing the PML-RAR alpha protein in U937 myeloid precursor cells showed that they lost the capacity to differentiate under the action of different stimuli, acquired enhanced sensitivity to retinoic acid, and exhibited a higher growth rate consequent to diminished apoptotic cell death.
Journal ArticleDOI
Acute promyelocytic leukemia: from genetics to treatment.
Francesco Grignani,Marta Fagioli,Myriam Alcalay,Letizia Longo,P P Pandolfi,Emilio Donti,Andrea Biondi,F. Lo Coco,Pier Giuseppe Pelicci +8 more
Journal ArticleDOI
A PMLRARα transgene initiates murine acute promyelocytic leukemia
Diane Storer Brown,Scott C. Kogan,Eric Lagasse,Irving L. Weissman,Myriam Alcalay,Pier Giuseppe Pelicci,Susan K. Atwater,J. Michael Bishop +7 more
TL;DR: The transgenic mice described here provide an apparently accurate model for human APL that includes clear evidence of tumor progression and should be useful for exploring the molecular pathogenesis of APL and the mechanisms of the therapeutic response to retinoic acid.
Journal ArticleDOI
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance.
Myriam Alcalay,Enrico Tiacci,Roberta Bergomas,Barbara Bigerna,Elisa Venturini,Simone Minardi,Natalia Meani,Daniela Diverio,Loris Bernard,Laura Tizzoni,Sara Volorio,Lucilla Luzi,Emanuela Colombo,Francesco Lo Coco,Cristina Mecucci,B. Falini,Pier Giuseppe Pelicci +16 more
TL;DR: The molecular signature of NPMc+ AML includes up-regulation of several genes putatively involved in the maintenance of a stem-cell phenotype, suggesting that NPM c- AML may derive from a multipotent hematopoietic progenitor.