P
Partha Chakrabarti
Researcher at Indian Institute of Chemical Biology
Publications - 301
Citations - 3668
Partha Chakrabarti is an academic researcher from Indian Institute of Chemical Biology. The author has contributed to research in topics: Formal verification & Search algorithm. The author has an hindex of 29, co-authored 276 publications receiving 3211 citations. Previous affiliations of Partha Chakrabarti include Boston University & Council of Scientific and Industrial Research.
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Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage.
TL;DR: It is demonstrated that mTORC1 promotes fat storage in mammalian cells by suppression of lipolysis and stimulation of de novo lipogenesis.
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FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes.
TL;DR: It is shown that the promotor region of the rate-limiting lipolytic enzyme, adipose triglyceride lipase (ATGL), has two FoxO1-binding sites, and co-transfection with wild type and unphosphorylatedFoxO1 mutant activates the expression of luciferase driven by the ATGL promotor.
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SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL
Partha Chakrabarti,Taylor English,Shakun Karki,Li Qiang,Rong Tao,Ju-Youn Kim,Zhijun Luo,Stephen R. Farmer,Konstantin V. Kandror +8 more
TL;DR: It is concluded that knockdown of SIRT1 with the help of small hairpin RNA decreases basal and isoproterenol-stimulated lipolysis in cultured adipocytes and controls ATGL transcription primarily by deacetylating FoxO1.
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Insulin Inhibits Lipolysis in Adipocytes via the Evolutionarily Conserved mTORC1-Egr1-ATGL-Mediated Pathway
Partha Chakrabarti,Ju Youn Kim,Maneet Singh,Yu-Kyong Shin,Jessica E. Kim,Joerg Kumbrink,Yuanyuan Wu,Mi-Jeong Lee,Kathrin H. Kirsch,Susan K. Fried,Konstantin V. Kandror +10 more
TL;DR: It is suggested that the evolutionarily conserved mTORC1-Egr1-ATGL regulatory pathway represents an important component of the antilipolytic effect of insulin in the mammalian organism.
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Distance functions in digital geometry
TL;DR: The necessary and sufficient condition for such distance functions to satisfy the properties of a metric has been derived and certain practical and efficient methods to check for metric properties are presented.