L
Li Qiang
Researcher at Columbia University
Publications - 48
Citations - 3791
Li Qiang is an academic researcher from Columbia University. The author has contributed to research in topics: Adipose tissue & Adipogenesis. The author has an hindex of 21, co-authored 44 publications receiving 3185 citations. Previous affiliations of Li Qiang include Columbia University Medical Center & Boston University.
Papers
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Journal ArticleDOI
Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
Li Qiang,Liheng Wang,Ning Kon,Wenhui Zhao,Sangkyu Lee,Yiying Zhang,Michael Rosenbaum,Yingming Zhao,Wei Gu,Stephen R. Farmer,Domenico Accili +10 more
TL;DR: It is proposed that SirT1-dependent P parγ deacetylation is a form of selective Pparγ modulation of potential therapeutic import in order to staunch the current obesity epidemic.
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Structure-based prediction of protein–protein interactions on a genome-wide scale
Qiangfeng Cliff Zhang,Donald Petrey,Donald Petrey,Lei Deng,Lei Deng,Li Qiang,Yu Shi,Chan Aye Thu,Brygida Bisikirska,Celine Lefebvre,Domenico Accili,Tony Hunter,Tom Maniatis,Andrea Califano,Barry Honig,Barry Honig +15 more
TL;DR: Three-dimensional structural information can be used to predict PPIs with an accuracy and coverage that are superior to predictions based on non-structural evidence, and an algorithm, termed PrePPI, which combines structural information with other functional clues is comparable in accuracy to high-throughput experiments.
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Adiponectin Secretion Is Regulated by SIRT1 and the Endoplasmic Reticulum Oxidoreductase Ero1-Lα
TL;DR: It is demonstrated that the endoplasmic reticulum (ER) oxidoreductase Ero1-Lα and effectors modulating peroxisome proliferator-activated receptor γ (PPARγ) and SIRT1 activities regulate secretion of adiponectin from 3T3-L1 adipocytes.
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C/EBPα and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor γ agonists
Cecile Vernochet,Sidney B. Peres,Katie Ellen Davis,Meghan E. McDonald,Li Qiang,Hong Wang,Philipp E. Scherer,Stephen R. Farmer +7 more
TL;DR: It is demonstrated that this phenotypic conversion is characterized by repression of a set of white fat genes, including the resistin, angiotensinogen, and chemerin genes, in addition to induction of brown-specific genes, such as Ucp-1.
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Activation of CCAAT/Enhancer-binding Protein (C/EBP) α Expression by C/EBPβ during Adipogenesis Requires a Peroxisome Proliferator-activated Receptor-γ-associated Repression of HDAC1 at the C/ebpα Gene Promoter
TL;DR: It is demonstrated that inhibition of PPARγ activity by exposure of 3T3-L1 preadipocytes to a potent and selective PParγ antagonist inhibits adipogenesis but also blocks the activation of C/EBPα expression at the onset of differentiation.