P
Pascal Sati
Researcher at National Institutes of Health
Publications - 94
Citations - 3790
Pascal Sati is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Multiple sclerosis & Magnetic resonance imaging. The author has an hindex of 26, co-authored 77 publications receiving 2534 citations. Previous affiliations of Pascal Sati include Washington University in St. Louis & Cedars-Sinai Medical Center.
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Journal ArticleDOI
Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI.
Martina Absinta,Seung Kwon Ha,Govind Nair,Pascal Sati,Nicholas J. Luciano,Maryknoll Palisoc,Antoine Louveau,Kareem A. Zaghloul,Stefania Pittaluga,Jonathan Kipnis,Daniel S. Reich +10 more
TL;DR: The existence of meningeal lymphatic vessels in human and nonhuman primates and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI hold promise for better understanding the normal physiology of lymphatic drainage from the central nervous system and potential aberrations in neurological diseases.
Journal ArticleDOI
Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo.
Martina Absinta,Pascal Sati,Federica Masuzzo,Govind Nair,Varun Sethi,Hadar Kolb,Joan Ohayon,Tianxia Wu,Irene Cortese,Daniel S. Reich +9 more
TL;DR: Investigation of chronic rim lesions on 7-T or 3-T susceptibility-based brain MRI in 192 patients with MS and the association of rim counts with clinical disability and brain volume changes prompted the planning of MRI-based clinical trials aimed at treating perilesional chronic inflammation in MS.
Journal ArticleDOI
The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative.
Pascal Sati,Jiwon Oh,R. Todd Constable,Nikos Evangelou,Charles R.G. Guttmann,Roland G. Henry,Eric C. Klawiter,Caterina Mainero,Luca Massacesi,Henry F. McFarland,Flavia Nelson,Daniel Ontaneda,Alexander Rauscher,William D. Rooney,Amal P. R. Samaraweera,Russell T. Shinohara,Raymond A. Sobel,Andrew J. Solomon,Constantina A. Treaba,Jens Wuerfel,Robert Zivadinov,Nancy L. Sicotte,Daniel Pelletier,Daniel S. Reich +23 more
TL;DR: In this article, the authors provide statements and recommendations aimed at helping radiologists and neurologists to better understand, refine, standardize and evaluate the central vein sign (CVS) in the diagnosis of MS.
Journal ArticleDOI
Gadolinium-based MRI characterization of leptomeningeal inflammation in multiple sclerosis.
Martina Absinta,Luisa Vuolo,Anuradha Rao,Govind Nair,Pascal Sati,Irene Cortese,Joan Ohayon,Kaylan Fenton,María I. Reyes-Mantilla,Dragan Maric,Peter A. Calabresi,John A. Butman,Carlos A. Pardo,Daniel S. Reich +13 more
TL;DR: Leptomeningeal contrast enhancement occurs frequently in MS and is a noninvasive, in vivo marker of inflammation and associated subpial demyelination, which might enable testing of new treatments aimed at eliminating this inflammation and potentially arresting progressive MS.
Journal ArticleDOI
Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions
Martina Absinta,Martina Absinta,Pascal Sati,Matthew K. Schindler,Emily C. Leibovitch,Joan Ohayon,Tianxia Wu,Alessandro Meani,Massimo Filippi,Steven Jacobson,Irene Cortese,Daniel S. Reich +11 more
TL;DR: Early lesion evolution, a persistent phase rim in lesions that shrink least and become more T1 hypointense over time suggests that the rim might mark failure of early lesion repair and/or irreversible tissue damage.