E
Edward G. Brooks
Researcher at University of Texas Health Science Center at San Antonio
Publications - 59
Citations - 3491
Edward G. Brooks is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Asthma & Mountain cedar. The author has an hindex of 25, co-authored 58 publications receiving 3139 citations. Previous affiliations of Edward G. Brooks include University of Texas Medical Branch & University of Texas at Austin.
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Journal ArticleDOI
Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype
Kathleen B. Bamford,Xuejun Fan,Sheila E. Crowe,James F. Leary,William K. Gourley,Gurinder Luthra,Edward G. Brooks,David Y. Graham,Victor E. Reyes,Peter B. Ernst +9 more
TL;DR: Observations show that gastric T cells resemble the Th1 type, which may explain their failure to induce immunity to H. pylori and their ability to contribute to the pathogenesis of gastric disease.
Journal ArticleDOI
Newborn Screening for Severe Combined Immunodeficiency in 11 Screening Programs in the United States
Antonia Kwan,Roshini S. Abraham,Robert Currier,Amy Brower,Karen Andruszewski,Jordan K. Abbott,Mei W. Baker,Mark Ballow,Louis Bartoshesky,Francisco A. Bonilla,Charles D. Brokopp,Edward G. Brooks,Michele Caggana,Jocelyn Celestin,Joseph A. Church,Anne Marie Comeau,James A. Connelly,Morton J. Cowan,Charlotte Cunningham-Rundles,Trivikram Dasu,Nina Dave,Maria Teresa de la Morena,Ulrich A. Duffner,Chin-To Fong,Lisa R. Forbes,Lisa R. Forbes,Debra Freedenberg,Erwin W. Gelfand,Jaime E. Hale,I. Celine Hanson,I. Celine Hanson,Beverly N. Hay,Diana Hu,Anthony J. Infante,Daisy Johnson,Neena Kapoor,Denise M. Kay,Donald B. Kohn,Rachel Lee,Heather K. Lehman,Zhili Lin,Fred Lorey,Aly Abdel-Mageed,Adrienne Manning,Sean A. McGhee,Sean A. McGhee,Theodore B. Moore,Stanley J. Naides,Luigi D. Notarangelo,Jordan S. Orange,Jordan S. Orange,Sung-Yun Pai,Matthew H. Porteus,Matthew H. Porteus,Ray Rodriguez,Neil Romberg,John M. Routes,Mary Ruehle,Arye Rubenstein,Carlos A. Saavedra-Matiz,Ginger Scott,Patricia M. Scott,Elizabeth Secord,Christine M. Seroogy,William T. Shearer,William T. Shearer,Subhadra Siegel,Stacy K. Silvers,E. Richard Stiehm,Robert W. Sugerman,John L. Sullivan,Susan Tanksley,Millard L. Tierce,James W. Verbsky,Beth Vogel,Rosalyn Walker,Kelly Walkovich,Jolan E. Walter,Richard L. Wasserman,Michael S. Watson,Geoffrey A. Weinberg,Leonard B. Weiner,Heather Wood,Anne B. Yates,Jennifer M. Puck +84 more
TL;DR: Newborn screening in 11 programs in the United States identified SCID in 1 in 58,000 infants, with high survival, and the usefulness of detection of non-SCID T-cell lymphopenia by the same screening remains to be determined.
Journal ArticleDOI
V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations.
Anna Villa,Cristina Sobacchi,Luigi D. Notarangelo,Fabio Bozzi,Mario Abinun,Tore G. Abrahamsen,Peter D. Arkwright,Michal Baniyash,Edward G. Brooks,Mary Ellen Conley,Patricia Cortes,Marzia Duse,Anders Fasth,Alexandra M. Filipovich,Anthony J. Infante,Alison L Jones,Evelina Mazzolari,Susanna M. Müller,Srdjan Pasic,Gideon Rechavi,Maria Grazia Sacco,Sandro Santagata,Marlis L. Schroeder,Reinhard Seger,Dario Strina,Alberto G. Ugazio,Jouni Väliaho,Mauno Vihinen,Larry B. Vogler,Hans D. Ochs,Paolo Vezzoni,Wilhelm Friedrich,Klaus Schwarz +32 more
TL;DR: The clinical and immunologic phenotypes of patients bearing mutations in RAGs are more diverse than previously thought and that this variability is related, in part, to the specific type of RAG mutation.
Journal ArticleDOI
Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx.
Masafumi Zaitsu,Shin Ichiro Narita,K. Chad Lambert,James J. Grady,D. Mark Estes,Edward M. Curran,Edward G. Brooks,Cheryl S. Watson,Randall M. Goldblum,Terumi Midoro-Horiuti +9 more
TL;DR: Binding of physiological concentrations of estradiol to a membrane estrogen receptor-alpha initiates a rapid onset and progressive influx of extracellular Ca(2+), which supports the synthesis and release of allergic mediators.
Journal ArticleDOI
Environmental Estrogens Induce Mast Cell Degranulation and Enhance IgE-Mediated Release of Allergic Mediators
Shin Ichiro Narita,Randall M. Goldblum,Cheryl S. Watson,Edward G. Brooks,D. Mark Estes,Edward M. Curran,Terumi Midoro-Horiuti +6 more
TL;DR: The findings suggest that estrogenic environmental pollutants might promote allergic diseases by inducing and enhancing mast cell degranulation by physiologic estrogens and exposure to allergens.