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Patricia L. Opresko
Researcher at University of Pittsburgh
Publications - 109
Citations - 6111
Patricia L. Opresko is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Telomere & DNA repair. The author has an hindex of 40, co-authored 94 publications receiving 5403 citations. Previous affiliations of Patricia L. Opresko include New York Medical College & Pennsylvania State University.
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Journal ArticleDOI
Human RecQ helicases in DNA repair, recombination, and replication.
TL;DR: Future research goals in this field include a better understanding of the division of labor among the human Rec Q helicases and learning how human RecQ helicases collaborate and cooperate to enhance genome stability.
Journal ArticleDOI
Telomere-binding Protein TRF2 Binds to and Stimulates the Werner and Bloom Syndrome Helicases
Patricia L. Opresko,Cayetano von Kobbe,Jean-Philippe Laine,Jean-Philippe Laine,Jeanine A. Harrigan,Ian D. Hickson,Vilhelm A. Bohr +6 more
TL;DR: In human cells, it is reported that WRN co-localizes and physically interacts with the critical telomere maintenance protein TRF2, and this interaction is mediated by the RecQ conserved C-terminal region of WRN.
Journal ArticleDOI
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.
Patricia L. Opresko,Marit Otterlei,Jesper Graakjaer,Per Bruheim,Lale Dawut,Steen Kølvraa,Alfred May,Michael M. Seidman,Vilhem A Bohr +8 more
TL;DR: It is found that WRN associates with telomeres when dissociation of telomeric D loops is likely during replication and recombination, and proposed roles for WRN in dissociating telomere structures in telomerase-deficient cells are proposed.
Journal ArticleDOI
Cumulative Inflammatory Load Is Associated with Short Leukocyte Telomere Length in the Health, Aging and Body Composition Study
Aoife O'Donovan,Aoife O'Donovan,Matthew S. Pantell,Eli Puterman,Firdaus S. Dhabhar,Elizabeth H. Blackburn,Kristine Yaffe,Kristine Yaffe,Richard M. Cawthon,Patricia L. Opresko,Wen Chi Hsueh,Suzanne Satterfield,Anne B. Newman,Hilsa N. Ayonayon,Susan M. Rubin,Tamara B. Harris,Elissa S. Epel +16 more
TL;DR: These data provide the first large-scale demonstration of links between inflammatory markers and LTL in an older population and suggest that cumulative inflammatory load, as indexed by the combination of high levels of IL-6 and TNF-α, is associated with increased odds for short LTL.
Journal ArticleDOI
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.
Robert M. Brosh,Cayetano von Kobbe,Joshua A. Sommers,Parimal Karmakar,Patricia L. Opresko,Jason Piotrowski,Irina I. Dianova,Grigory L. Dianov,Vilhelm A. Bohr +8 more
TL;DR: A novel interaction of the WRN gene product with the human 5′ flap endonuclease/5′–3′ exonuclelease (FEN‐1), a DNA structure‐specific nuclease implicated in DNA replication, recombination and repair is reported.