P
Patrick S. Stumpf
Researcher at University of Southampton
Publications - 43
Citations - 1063
Patrick S. Stumpf is an academic researcher from University of Southampton. The author has contributed to research in topics: Stem cell & Embryonic stem cell. The author has an hindex of 11, co-authored 40 publications receiving 846 citations. Previous affiliations of Patrick S. Stumpf include Fraunhofer Society & Southampton General Hospital.
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Journal ArticleDOI
Light-modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium beggiatoa
Manuela Stierl,Patrick S. Stumpf,Daniel Udwari,Ronnie Gueta,Rolf Hagedorn,Aba Losi,Wolfgang Gärtner,Linda Petereit,Marina Efetova,Martin Schwärzel,Thomas G. Oertner,Georg Nagel,Peter Hegemann +12 more
TL;DR: In this article, a photoactivated adenylyl cyclase (bPAC) was identified in the genome of the bacterium Beggiatoa and showed cyclase activity that was low in darkness but increased 300-fold in the light.
Journal ArticleDOI
Stem Cell Differentiation as a Non-Markov Stochastic Process.
Patrick S. Stumpf,Rosanna C.G. Smith,Michael Lenz,Michael Lenz,Andreas Schuppert,Franz-Josef Müller,Ann C. Babtie,Thalia E. Chan,Michael P. H. Stumpf,Colin P. Please,Sam Howison,Fumio Arai,Ben D. MacArthur +12 more
TL;DR: A statistical mechanics interpretation of these results that distinguishes between functionally distinct cellular “macrostates” and functionally similar molecular “microstates” is suggested and a model of stem cell differentiation as a non-Markov stochastic process is proposed.
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Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity
Ben D. MacArthur,Ana Sevilla,Michael Lenz,Franz-Josef Müller,Berhard M Schuldt,Andreas Schuppert,Sonya J. Ridden,Patrick S. Stumpf,Miguel Fidalgo,Avi Ma'ayan,Jianlong Wang,Ihor R. Lemischka +11 more
TL;DR: It is found that early molecular changes subsequent to Nanog loss are stochastic and reversible, and exogenous regulation of Nanog-dependent feedback control mechanisms produced a more homogeneous ES cell population.
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Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation.
Ayako Nakamura-Ishizu,Ayako Nakamura-Ishizu,Takayoshi Matsumura,Patrick S. Stumpf,Terumasa Umemoto,Hitoshi Takizawa,Yuji Takihara,Aled O'Neil,A'Qilah Majeed,Ben D. MacArthur,Ben D. MacArthur,Toshio Suda,Toshio Suda +12 more
TL;DR: It is shown that Thpo rapidly upregulates mitochondrial activity in HSCs, an activity accompanied by differentiation to an Mk lineage, and an important role for Thpo in regulating rapid Mk-lineage commitment is reported.
Journal ArticleDOI
MicroRNA-146a regulates human foetal femur derived skeletal stem cell differentiation by down-regulating SMAD2 and SMAD3.
Kelvin S. C. Cheung,Nunzia Sposito,Patrick S. Stumpf,David I. Wilson,Tilman Sanchez-Elsner,Richard O.C. Oreffo +5 more
TL;DR: The current findings indicate miR-146a plays an important role in skeletogenesis through attenuation of SMAD2 and SMAD3 function and provide further insight into the role of miRs in human skeletal stem cell differentiation modulation with implications therein for bone reparation.