P
Patrick Schaub
Researcher at University of Freiburg
Publications - 23
Citations - 1348
Patrick Schaub is an academic researcher from University of Freiburg. The author has contributed to research in topics: Phytoene desaturase & Phytoene synthase. The author has an hindex of 16, co-authored 21 publications receiving 1150 citations. Previous affiliations of Patrick Schaub include University of Freiburg Faculty of Biology.
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Journal ArticleDOI
Golden Rice: Introducing the β-Carotene Biosynthesis Pathway into Rice Endosperm by Genetic Engineering to Defeat Vitamin A Deficiency
Peter Beyer,Salim Al-Babili,Xudong Ye,Xudong Ye,Paola Lucca,Patrick Schaub,Ralf Welsch,Ingo Potrykus +7 more
TL;DR: A hypothesis is developed that trans-lycopene or a trans-allycopene derivative acts as an inductor in a kind of feedback mechanism stimulating endogenous carotenogenic genes in rice endosperm.
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Why is golden rice golden (yellow) instead of red
TL;DR: The transgenic phenotype is not due to up-regulation of expression of the endogenous rice pathway in response to the transgenes, as was suggested to be the case in tomato (Lycopersicon esculentum) fruit, where CRTI expression resulted in a similar carotenoid phenomenon.
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Golden Indica and Japonica rice lines amenable to deregulation.
TL;DR: To carry the invention beyond its initial “proof-of-concept” status in a Japonica rice (Oryza sativa) cultivar, two transformed elite Indica varieties (IR64 and MTL250) plus one Japonicas variety Taipei 309 are reported here on.
Journal ArticleDOI
On the structure and function of the phytoene desaturase CRTI from Pantoea ananatis, a membrane-peripheral and FAD-dependent oxidase/isomerase.
Patrick Schaub,Qiuju Yu,Sandra Gemmecker,Pierre Poussin-Courmontagne,J. Mailliot,Alastair G. McEwen,Sandro Ghisla,Salim Al-Babili,Jean Cavarelli,Peter Beyer +9 more
TL;DR: This property renders CRTI a valuable gene to engineer provitamin A-formation to help combat vitamin A malnutrition, such as with Golden Rice, and a membrane-peripheral oxidoreductase which utilizes FAD as the sole redox-active cofactor.
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Enzymatic study on AtCCD4 and AtCCD7 and their potential to form acyclic regulatory metabolites.
Mark Bruno,Julian Koschmieder,Florian Wuest,Patrick Schaub,M. Fehling-Kaschek,Jens Timmer,Peter Beyer,Salim Al-Babili +7 more
TL;DR: In vitro study shows that AtCCD4 claves all-trans-bicyclic-carotenoids, excludes its direct involvement in generating plastid retrograde signals supposedly derived from cis-desaturation intermediates, and demonstrates that At CCD7 converts 9-cis-acylic carotenes.