V
Vicki Seyfert-Margolis
Researcher at University of California, San Francisco
Publications - 23
Citations - 6528
Vicki Seyfert-Margolis is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Immunosuppression & Immune tolerance. The author has an hindex of 17, co-authored 23 publications receiving 5968 citations. Previous affiliations of Vicki Seyfert-Margolis include Food and Drug Administration.
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Journal ArticleDOI
Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis
John H. Stone,Peter A. Merkel,Robert Spiera,Philip Seo,Carol A. Langford,Gary S. Hoffman,Cees G. M. Kallenberg,E. William St. Clair,Anthony M. Turkiewicz,Nadia K. Tchao,Lisa Webber,Linna Ding,Lourdes P. Sejismundo,Kathleen Mieras,David Weitzenkamp,David Ikle,Vicki Seyfert-Margolis,Mark Mueller,Paul Brunetta,Nancy B. Allen,Fernando C. Fervenza,Duvuru Geetha,Karina A. Keogh,Eugene Y. Kissin,Paul A. Monach,Tobias Peikert,Coen A. Stegeman,Steven R. Ytterberg,Ulrich Specks +28 more
TL;DR: Rituximab therapy was not inferior to daily cyclophosphamide treatment for induction of remission in severe ANCA-associated vasculitis and may be superior in relapsing disease.
Journal ArticleDOI
International Trial of the Edmonton Protocol for Islet Transplantation
A. M. James Shapiro,Camillo Ricordi,Bernhard J. Hering,Hugh Auchincloss,Robert Lindblad,R. Paul Robertson,Antonio Secchi,Mathias D. Brendel,Thierry Berney,Daniel C. Brennan,Enrico Cagliero,Rodolfo Alejandro,Edmond A. Ryan,Barbara S. Dimercurio,Philippe Morel,Kenneth S. Polonsky,Jo Anna Reems,Reinhard G. Bretzel,Federico Bertuzzi,Tatiana Froud,Raja Kandaswamy,David E.R. Sutherland,George S. Eisenbarth,Miriam Segal,Jutta K. Preiksaitis,Gregory S. Korbutt,Franca B. Barton,Lisa Viviano,Vicki Seyfert-Margolis,Jeffrey A. Bluestone,Jonathan R. T. Lakey +30 more
TL;DR: Islet transplantation with the use of the Edmonton protocol can successfully restore long-term endogenous insulin production and glycemic stability in subjects with type 1 diabetes mellitus and unstable control, but insulin independence is usually not sustainable.
Journal ArticleDOI
Identification of a B cell signature associated with renal transplant tolerance in humans
Kenneth A. Newell,Adam Asare,Allan D. Kirk,Trang D. Gisler,Kasia Bourcier,Manikkam Suthanthiran,William J. Burlingham,William H. Marks,Ignacio Sanz,Robert I. Lechler,Maria P. Hernandez-Fuentes,Laurence A. Turka,Laurence A. Turka,Vicki Seyfert-Margolis +13 more
TL;DR: Results point to a critical role for B cells in regulating alloimmunity and provide a candidate set of genes for wider-scale screening of renal transplant recipients.
Journal ArticleDOI
Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans
Pervinder Sagoo,Esperanza Perucha,Birgit Sawitzki,Stefan Tomiuk,David A. Stephens,Patrick Miqueu,S Chapman,Ligia Craciun,Ruhena Sergeant,Sophie Brouard,Flavia Rovis,Elvira Jimenez,Amany Ballow,Magali Giral,Irene Rebollo-Mesa,Alain Le Moine,Cécile Braudeau,Rachel Hilton,Bernhard Gerstmayer,Katarzyna Bourcier,Adnan Sharif,Magdalena Krajewska,Graham M. Lord,Ian S.D. Roberts,Michel Goldman,Kathryn J. Wood,Kenneth A. Newell,Vicki Seyfert-Margolis,Anthony N. Warrens,Uwe Janssen,Hans-Dieter Volk,Jean-Paul Soulillou,Maria P. Hernandez-Fuentes,Robert I. Lechler +33 more
TL;DR: An immunological profile of the tolerant state is provided that, with further validation, should inform and shape drug-weaning protocols in renal transplant recipients.
Journal ArticleDOI
Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays
TL;DR: parameters which are essential for measurement of cytokines in the context of clinical trials are shown, including blood collecting tubes, duration of storage, and number of freeze thawing cycles.