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Paul Billings
Researcher at Natera
Publications - 56
Citations - 2249
Paul Billings is an academic researcher from Natera. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 13, co-authored 42 publications receiving 1022 citations. Previous affiliations of Paul Billings include Life Technologies.
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Journal ArticleDOI
Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer.
Thomas Reinert,Tenna V Henriksen,Emil Christensen,Shruti Sharma,Raheleh Salari,Himanshu Sethi,Michael Knudsen,Iver Nordentoft,Hsin-Ta Wu,Antony Tin,Mads Rasmussen,Søren Vang,Svetlana Shchegrova,Amanda Frydendahl Boll Johansen,Ramya Srinivasan,Zoe June Assaf,Mustafa Balcioglu,Alexander Olson,Scott Dashner,Dina Hafez,Samantha Navarro,Shruti Goel,Matthew Rabinowitz,Paul Billings,Styrmir Sigurjonsson,Lars Dyrskjøt,Ryan Swenerton,Alexey Aleshin,Søren Laurberg,Anders Husted Madsen,Anne-Sofie Kannerup,Katrine Stribolt,Søren Krag,Lene Hjerrild Iversen,Kåre Gotschalck Sunesen,Cheng-Ho Jimmy Lin,Bernhard Zimmermann,Claus L. Andersen +37 more
TL;DR: This cohort study investigates the use of longitudinal data from ultradeep sequencing of cell-free DNA in Danish patients with colorectal cancer to find out if the data can be used to improve the prognosis of these patients.
Journal ArticleDOI
Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma.
Emil Christensen,Karin Birkenkamp-Demtröder,Himanshu Sethi,Svetlana Shchegrova,Raheleh Salari,Iver Nordentoft,Hsin-Ta Wu,Michael Knudsen,Philippe Lamy,Sia Viborg Lindskrog,Ann Taber,Mustafa Balcioglu,Søren Vang,Zoe June Assaf,Shruti Sharma,Antony Tin,Ramya Srinivasan,Dina Hafez,Thomas Reinert,Samantha Navarro,Alexander Olson,Rosalyn Ram,Scott Dashner,Matthew Rabinowitz,Paul Billings,Styrmir Sigurjonsson,Claus L. Andersen,Ryan Swenerton,Alexey Aleshin,Bernhard Zimmermann,Mads Agerbæk,Cheng-Ho Jimmy Lin,Jørgen Bjerggaard Jensen,Jørgen Bjerggaard Jensen,Lars Dyrskjøt,Lars Dyrskjøt +35 more
TL;DR: Table 1 shows that ctDNA assessment for early risk stratification, therapy monitoring, and early relapse detection in bladder cancer is feasible and provides a basis for clinical studies that evaluate early therapeutic interventions.
Journal ArticleDOI
Personalized Detection of Circulating Tumor DNA Antedates Breast Cancer Metastatic Recurrence
Raoul Charles Coombes,Karen Page,Raheleh Salari,Robert K. Hastings,Anne C Armstrong,Samreen Ahmed,Simak Ali,Susan Cleator,Laura M. Kenny,Justin Stebbing,Mark J. Rutherford,Himanshu Sethi,Anna Rita Boydell,Ryan Swenerton,Daniel Fernandez-Garcia,Kelly L. T. Gleason,K. Goddard,David S. Guttery,Zoe June Assaf,Hsin-Ta Wu,Prashanthi Natarajan,David Moore,L Primrose,Scott Dashner,Antony Tin,Mustafa Balcioglu,Ramya Srinivasan,Svetlana Shchegrova,Alexander Olson,Dina Hafez,Paul Billings,Alexey Aleshin,Farah Rehman,Bradley J. Toghill,Allison Hills,Maggie C. Louie,Cheng-Ho Jimmy Lin,Bernhard Zimmermann,Jaqueline A. Shaw +38 more
TL;DR: This study demonstrates that patient-specific ctDNA analysis can be a sensitive and specific approach for disease surveillance for patients with breast cancer, and earlier detection of up to 2 years provides a possible window for therapeutic intervention.
Journal ArticleDOI
Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab
Scott V. Bratman,Scott V. Bratman,S. Y. Cindy Yang,S. Y. Cindy Yang,Marco A. J. Iafolla,Marco A. J. Iafolla,Zhihui Liu,Zhihui Liu,Aaron R. Hansen,Aaron R. Hansen,Philippe L. Bedard,Philippe L. Bedard,Stephanie Lheureux,Stephanie Lheureux,Anna Spreafico,Anna Spreafico,Albiruni Ryan Abdul Razak,Albiruni Ryan Abdul Razak,Svetlana Shchegrova,Maggie C. Louie,Paul Billings,Bernhard Zimmermann,Himanshu Sethi,Alexey Aleshin,Dax Torti,Kayla Marsh,Jenna Eagles,Iulia Cirlan,Youstina Hanna,Derek L. Clouthier,Scott C. Lien,Scott C. Lien,Pamela S. Ohashi,Pamela S. Ohashi,Wei Xu,Wei Xu,Lillian L. Siu,Lillian L. Siu,Trevor J. Pugh,Trevor J. Pugh +39 more
TL;DR: The potential for broad clinical utility of ctDNA-based surveillance in patients treated with ICB is demonstrated, and 12 patients with ct DNA clearance during treatment were alive with median 25 months follow up.
Journal ArticleDOI
Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities
David Craig,Joyce O'Shaughnessy,Jeff Kiefer,Jessica Aldrich,Shripad Sinari,Tracy M. Moses,Shukmei Wong,Jennifer Dinh,Alexis Christoforides,Joanne L. Blum,Cristi L Aitelli,Cynthia Osborne,Tyler Izatt,Ahmet Kurdoglu,Angela Baker,Julie Koeman,Catalin Barbacioru,Onur Sakarya,Francisco M. De La Vega,Asim Siddiqui,Linh Hoang,Paul Billings,Bodour Salhia,Anthony W. Tolcher,Jeffrey M. Trent,Spyro Mousses,Daniel D. Von Hoff,John D. Carpten +27 more
TL;DR: In conclusion, whole genome and transcriptome profiling of mTNBC have provided insights into somatic events occurring in this difficult to treat cancer.