Paul D. Smith

TL;DR: It is concluded that latent EBV initiates a chain of events that leads to epigenetic repression of the tumour suppressor gene Bim in infected B cells and their progeny and this reprogramming of B cells could have important implications for the understanding of EBV persistence and the pathogenesis ofEBV-associated disease, in particular BL.

TL;DR: Common themes and approaches have been identified which have been utilized to successfully target emerging mechanisms of resistance and include the increase in target potency and selectivity, alternative chemical scaffolds, change of mechanism of action (covalents, PROTACs), increases in blood-brain barrier permeability (BBBP), and the targeting of allosteric pockets.

TL;DR: In this paper, the use of NIR semiconductor nanocrystals in deep-tissue in vivo optical imaging is reported, which is a useful angiographic contrast agent for vessels surrounding and penetrating a murine squamous cell carcinoma in a C3H mouse.

TL;DR: The findings highlight the significance of OxPhos in melanoma and suggest that combined targeting of the MAPK and mTORC pathways may offer an effective therapeutic strategy to treat melanomas with this metabolic phenotype.

TL;DR: It is found that Pin1 is required for efficient loading of p53 on target promoters upon stress and is recruited to chromatin by p53 and stimulates binding of the p300 acetyltransferase and consequent p53 acetylation.