J
Javier E. Girardini
Researcher at National Scientific and Technical Research Council
Publications - 23
Citations - 738
Javier E. Girardini is an academic researcher from National Scientific and Technical Research Council. The author has contributed to research in topics: Mutant & Ferredoxin. The author has an hindex of 10, co-authored 19 publications receiving 672 citations. Previous affiliations of Javier E. Girardini include Facultad de Ciencias Médicas & AREA Science Park.
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Journal ArticleDOI
A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.
Javier E. Girardini,Javier E. Girardini,Marco Napoli,Marco Napoli,Silvano Piazza,Alessandra Rustighi,Alessandra Rustighi,Carolina Marotta,Carolina Marotta,Enrico Radaelli,Valeria Capaci,Valeria Capaci,Lee B. Jordan,Phil Quinlan,Alastair M. Thompson,Alastair M. Thompson,Miguel Mano,Antonio Rosato,Tim Crook,Eugenio Scanziani,Anthony R. Means,Guillermina Lozano,Claudio Schneider,Claudio Schneider,Giannino Del Sal,Giannino Del Sal +25 more
TL;DR: A Pin1/mutant p53 axis that conveys oncogenic signals to promote aggressiveness in human cancers is defined and a transcriptional signature associated with poor prognosis in breast cancer and Pin1 overexpression influenced the prognostic value of p53 mutation is identified.
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The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP
Fiamma Mantovani,Francesca Tocco,Javier E. Girardini,Paul D. Smith,Milena Gasco,Xin Lu,Tim Crook,Giannino Del Sal +7 more
TL;DR: It is found that Pin1 is required for efficient loading of p53 on target promoters upon stress and is recruited to chromatin by p53 and stimulates binding of the p300 acetyltransferase and consequent p53 acetylation.
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Molecular detection of Histoplasma capsulatum var. capsulatum in human clinical samples
Andrea B. J. Bracca,María Elena Tosello,Javier E. Girardini,Susana L. Amigot,Carlos Gomez,Esteban Serra +5 more
TL;DR: A seminested PCR for the diagnosis of histoplasmosis that amplifies a portion of the Histoplasma capsulatum H antigen gene is developed that is highly sensitive and specific, being able to detect genomic material corresponding to less than 10 yeast cells without cross-reaction against other bacterial or fungal pathogens.
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Characterization of an omega-class glutathione S-transferase from Schistosoma mansoni with glutaredoxin-like dehydroascorbate reductase and thiol transferase activities
TL;DR: It is reported here that SmGSTO protein is a 28-kDa polypeptide, detected in all life stages of the parasite, being highly expressed in adult worms, and displayed significant glutathione-dependent dehydroascorbate reductase and thiol transferase enzymatic activities.
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Peptide aptamers targeting mutant p53 induce apoptosis in tumor cells.
Elisa Guida,Andrea Bisso,Cristina Fenollar-Ferrer,Marco Napoli,Claudio Anselmi,Javier E. Girardini,Paolo Carloni,Giannino Del Sal +7 more
TL;DR: Transient expression of PAs was able to reduce the transactivation activity of Mutant p53 and to induce apoptosis specifically in cells expressing mutant p53, which could provide a potential strategy to inhibit the oncogenic functions of mutant p52 and improve mutant p 53-targeted cancer therapies.