Gulietta M. Pupo

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: Analysis of whole-genome sequences from cutaneous, acral and mucosal subtypes of melanoma reveals diverse carcinogenic processes across its subtypes, some unrelated to sun exposure, and extends potential involvement of the non-coding genome in its pathogenesis.

TL;DR: The three main Shigella clusters are estimated to have evolved within the last 35,000 to 270,000 years, suggesting that shigellosis was one of the early infectious diseases of humans.

TL;DR: Selecting sequential drugs based on the molecular characteristics of a single progressing biopsy is unlikely to provide improved responses, and first-line therapies targeting multiple pathways will be required.

TL;DR: The results suggest the possibility that any E. coli strain acquiring the appropriate virulence factors may give rise to a pathogenic form, and that the genus Shigella is shown to comprise a group of closely related pathogenic E. Escherichia coli strains.