P
Paul E. Kennedy
Researcher at National Institutes of Health
Publications - 18
Citations - 12501
Paul E. Kennedy is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cell fusion & Immunotoxin. The author has an hindex of 15, co-authored 18 publications receiving 12330 citations. Previous affiliations of Paul E. Kennedy include Government of the United States of America.
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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
TL;DR: A cofactor for HIV-1 (human immunodeficiency virus-type 1) fusion and entry was identified with the use of a novel functional complementary DNA (cDNA) cloning strategy that is a putative G protein-coupled receptor with seven transmembrane segments.
Journal Article
HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein–Coupled Receptor
TL;DR: Fusin this article is a putative G protein-coupled receptor with seven transmembrane segments, which enabled CD4-expressing nonhuman cell types to support HIV-1 Env-mediated cell fusion and infection.
Journal ArticleDOI
CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1
Ghalib Alkhatib,Christophe Combadiere,Christopher C. Broder,Yu Feng,Paul E. Kennedy,Philip Murphy,Edward A. Berger +6 more
TL;DR: Recombinant CC CKR5, a G protein-coupled receptor for these chemokines, rendered CD4-expressing nonhuman cells fusion-competent preferentially with macrophage-tropic Envs, and is thus a fusion cofactor for HIV-1 strains.
Journal ArticleDOI
CD46 is a cellular receptor for human herpesvirus 6.
Fabio Santoro,Paul E. Kennedy,Giuseppe Locatelli,Mauro S. Malnati,Edward A. Berger,Paolo Lusso +5 more
TL;DR: It is shown that the two major HHV-6 subgroups (A and B) use human CD46 as a cellular receptor, and the use of a ubiquitous immunoregulatory receptor opens novel perspectives for understanding the tropism and pathogenicity of HHv-6.
Journal ArticleDOI
Inherited Resistance to HIV-1 Conferred by an Inactivating Mutation in CC Chemokine Receptor 5: Studies in Populations with Contrasting Clinical Phenotypes, Defined Racial Background, and Quantified Risk
Peter A. Zimmerman,Alicia Buckler-White,Ghalib Alkhatib,Todd Spalding,Joseph Kubofcik,Christophe Combadière,Drew Weissman,Oren J. Cohen,Andrea Rubbert,Gordon K. Lam,Mauro Vaccarezza,Paul E. Kennedy,V. Kumaraswami,Janis V. Giorgi,Roger Detels,Jay Hunter,Michael Chopek,Edward A. Berger,Anthony S. Fauci,Thomas B. Nutman,Philip M. Murphy +20 more
TL;DR: The data suggest that homozygous CCR5-2 is an HIV-1 resistance factor in Caucasians with complete penetrance, and that heterozygously CCR 5-2 slows the rate of disease progression in infected Caucasian homosexuals.