J
Jamie I. Fletcher
Researcher at University of New South Wales
Publications - 68
Citations - 8497
Jamie I. Fletcher is an academic researcher from University of New South Wales. The author has contributed to research in topics: Neuroblastoma & Cancer. The author has an hindex of 27, co-authored 61 publications receiving 7766 citations. Previous affiliations of Jamie I. Fletcher include Walter and Eliza Hall Institute of Medical Research & University of Sydney.
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Journal ArticleDOI
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
Lin Chen,Simon N. Willis,Andrew H. Wei,Brian J. Smith,Jamie I. Fletcher,Mark G. Hinds,Peter M. Colman,Catherine L. Day,Jerry M. Adams,David C.S. Huang +9 more
TL;DR: The results suggest that apoptosis relies on selective interactions between particular subsets of these proteins and that it should be feasible to discover BH3-mimetic drugs that inactivate specific prosurvival targets.
Journal ArticleDOI
Proapoptotic Bak Is Sequestered by Mcl-1 and Bcl-xL, but Not Bcl-2, Until Displaced by BH3-only Proteins
Simon N. Willis,Lin Chen,Grant Dewson,Andrew H. Wei,Edwina Naik,Jamie I. Fletcher,Jerry M. Adams,David C.S. Huang +7 more
TL;DR: The results indicate that Bak is held in check solely by Mcl-1 and Bcl-x(L) and induces apoptosis only if freed from both, and the finding that different prosurvival proteins have selective roles has notable implications for the design of anti-cancer drugs that target the B cl-2 family.
Journal ArticleDOI
Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak
Simon N. Willis,Jamie I. Fletcher,Thomas Kaufmann,Mark F. van Delft,Mark F. van Delft,Lin Chen,Peter E. Czabotar,Helen Ierino,Erinna F. Lee,Erinna F. Lee,W. Douglas Fairlie,Philippe Bouillet,Andreas Strasser,Ruth M. Kluck,Jerry M. Adams,David C.S. Huang +15 more
TL;DR: Contrary to the direct-activation model, it is shown that Bax and Bak can mediate apoptosis without discernable association with the putative BH3-only activators (Bim, Bid, and Puma).
Journal ArticleDOI
ABC transporters in cancer: more than just drug efflux pumps.
TL;DR: It is proposed that delineating the precise roles of these transporters in tumorigenesis and treatment response will be important for the development of more effective targeted therapies.
Journal ArticleDOI
Programmed Anuclear Cell Death Delimits Platelet Life Span
Kylie D. Mason,Marina R. Carpinelli,Jamie I. Fletcher,Janelle E. Collinge,Adrienne A. Hilton,Sarah Ellis,Priscilla N. Kelly,Paul G Ekert,Donald Metcalf,Andrew W. Roberts,David C.S. Huang,Benjamin T. Kile,Benjamin T. Kile +12 more
TL;DR: It is shown that an intrinsic program for apoptosis controls platelet survival and dictates their life span, and this represents an important paradigm for cellular homeostasis, and has profound implications for the diagnosis and treatment of disorders that affect platelet number and function.