P
Paul Hakimpour
Researcher at Rockefeller University
Publications - 8
Citations - 1273
Paul Hakimpour is an academic researcher from Rockefeller University. The author has contributed to research in topics: Somatic hypermutation & Immunoglobulin class switching. The author has an hindex of 6, co-authored 7 publications receiving 1116 citations. Previous affiliations of Paul Hakimpour include Emory University & Yerkes National Primate Research Center.
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Journal ArticleDOI
MicroRNA-155 Is a Negative Regulator of Activation-Induced Cytidine Deaminase
Grace Teng,Paul Hakimpour,Pablo Landgraf,Amanda J. Rice,Thomas Tuschl,Rafael Casellas,F. Nina Papavasiliou +6 more
TL;DR: It is shown that AID was regulated posttranscriptionally by a lymphocyte-specific microRNA, miR-155, and that it targeted a conserved site in the 3'-untranslated region of the mRNA encoding AID, which resulted in quantitative and temporal deregulation of AID expression.
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TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination.
Jason Z. Oh,Rajesh Ravindran,Benoit Chassaing,Frederic A. Carvalho,Frederic A. Carvalho,Mohan S. Maddur,Maureen A. Bower,Paul Hakimpour,Kiran Gill,Helder I. Nakaya,Helder I. Nakaya,Felix Yarovinsky,R. Balfour Sartor,Andrew T. Gewirtz,Bali Pulendran +14 more
TL;DR: An unappreciated role for gut microbiota in promoting immunity to vaccination is revealed, with TLR5-mediated sensing of the microbiota impacting antibody responses to the inactivated polio vaccine, but not to adjuvanted vaccines or the live-attenuated yellow fever vaccine.
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The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation
Rajesh Ravindran,Jens Loebbermann,Helder I. Nakaya,Nooruddin Khan,Hualing Ma,Leonardo dos Reis Gama,Deepa Machiah,Benton Lawson,Paul Hakimpour,Yi-chong Wang,Shuzhao Li,Prachi Sharma,Randal J. Kaufman,Jennifer Martinez,Bali Pulendran +14 more
TL;DR: It is demonstrated in mice that GCN2 controls intestinal inflammation by suppressing inflammasome activation and in vivo blockade of ROS and IL-1β resulted in inhibition of TH17 responses and reduced inflammation in Gcn2−/− mice.
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mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation
Charles Sinclair,Gayathri Bommakanti,Luiz Gustavo Gardinassi,Jens Loebbermann,Matthew Johnson,Matthew Johnson,Paul Hakimpour,Thomas Hagan,Lydia Benitez,Andrei Todor,Deepa Machiah,Timothy B. Oriss,Anuradha Ray,Steven E. Bosinger,Rajesh Ravindran,Shuzhao Li,Bali Pulendran,Bali Pulendran +17 more
TL;DR: It is found that mechanistic target of rapamycin (mTOR)–dependent metabolic adaptation was required at discrete locations, and mTOR mediates metabolic adaptation of APCs in distinct tissues, influencing the immunological character of allergic inflammation.
Journal ArticleDOI
Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region.
Wesley A. Dunnick,John Collins,Jian Shi,Gerwin Westfield,Clinton Fontaine,Paul Hakimpour,F. Nina Papavasiliou +6 more
TL;DR: It is found that in B cells with a transgene lacking the 3′ enhancers, interchromosomal recombination between the transgenic VDJ exon and the endogenous heavy chain C genes is more easily detected than CSR within the transGene.