Rajesh Ravindran

TL;DR: It is demonstrated that immunization of mice with synthetic nanoparticles containing antigens plus ligands that signal through TLR4 and TLR7 induces synergistic increases in antigen-specific, neutralizing antibodies compared to immunization with nanoparticles minus a single TLR ligand, and there was enhanced persistence of germinal centres and of plasma-cell responses, which persisted in the lymph nodes for >1.5 years.

TL;DR: It is reported here that the Wnt–β-catenin signaling in intestinal dendritic cells regulates the balance between inflammatory versus regulatory responses in the gut, limiting the inflammatory response.

TL;DR: An unappreciated role for gut microbiota in promoting immunity to vaccination is revealed, with TLR5-mediated sensing of the microbiota impacting antibody responses to the inactivated polio vaccine, but not to adjuvanted vaccines or the live-attenuated yellow fever vaccine.

TL;DR: It is demonstrated that cysteine protease–induced TH2 responses occur via 'cooperation' between migratory dermal dendritic cells (DCs) and basophils positive for interleukin 4 (IL-4) via ROS-mediated signaling.

TL;DR: A new mechanism for the systemic induction of retinoic acid and immune suppression against autoimmunity is defined, defined as Toll-like receptor 2 (TLR2) and dectin-1, recognizing the same microbial stimulus.