Benton Lawson

TL;DR: It is demonstrated in mice that GCN2 controls intestinal inflammation by suppressing inflammasome activation and in vivo blockade of ROS and IL-1β resulted in inhibition of TH17 responses and reduced inflammation in Gcn2−/− mice.

TL;DR: The in vivo effect of CD8+ lymphocyte depletion on the lifespan of productively infected cells during chronic SIVmac239 infection of rhesus macaques is assessed and it is found that, in both early (day 57 post-SIV) and late (day 177 post- SIV) chronic Siv infection, depletion of CD9+ lymphocytes did not result in a measurable increase in the lifespan.

TL;DR: It is shown that in SIV-infected RMs treated with short-term ART, depletion of CD8(+) lymphocytes resulted in increased plasma viremia in all animals and that repopulation of CD 8(+) T cells was associated with prompt reestablishment of virus control, suggesting a role for CD8 (+) T-cells in controlling viral production during ART, thus providing a rationale for exploring immunotherapeutic approaches in ART-treated HIV-infect

TL;DR: It is demonstrated that an activated immune microenvironment prior to vaccination impedes efficacy of the YF-17D vaccine in an African cohort and suggest that vaccine regimens may need to be boosted in African populations to achieve efficient immunity.

TL;DR: Findings indicate that the absence of AIDS in naturally SIV-infected sooty mangabeys is independent of a strong cellular immune response to the virus.