Paul J.D. Winyard

TL;DR: A role for HNF1B not only in nephrogenesis but also in the maintenance of tubular function is described, thus describing a role for a transcription factor expressed in tissues including renal epithelia and regulating transcription of FXYD2 in the tubular handling of Mg(2+).

TL;DR: These studies implicate conserved roles for Six2 and Bmp4 in the development of the renal system, which could affect kidney development at multiple stages, leading to the congenital anomalies observed in patients with RHD.

TL;DR: It is speculated that deregulation of cell survival in these kidneys may reflect incomplete tissue maturation, and may contribute to the progressive destruction of functional kidney tissue in polycystic kidneys and the spontaneous involution reported in cystic dysplastic kidneys.

TL;DR: Here, it is possible to begin to understand the normal nephrogenic function of the wild-type proteins and understand how mutations might cause aberrant organogenesis.

TL;DR: It is shown that during acquisition of epithelial polarity, OFD1 became localized to the apical zone of nephron precursor cells and then to basal bodies at the origin of primary cilia in fully differentiated epithelia, placing the protein at key sites, where it may play roles not only in microtubule organization (centrosomal function) but also in mechanosensation of urine flow (a primary ciliary function).