Paul Jenö

TL;DR: In this paper, the authors identify metabolites of the mevalonate pathway as the tumor ligands that activate TCR-γδ cells, and demonstrate that when metabolite accumulation is induced by overexpressing HMGR or by treatment with nitrogen-containing bisphosphonate drugs, tumor cells derived from many tissues acquire the capacity to stimulate the same T cell receptor (TCR-γα)-γα population.

TL;DR: The identification of Proline-rich Akt substrate (PRAS40) and the hypothetical protein Q6MZQ0/FLJ14213/CAE45978 as new mTOR binding proteins suggest that mTORC2-dissociated PRR5L may promote apoptosis when mTOR is hyperactive.

TL;DR: An unanticipated tumor recognition mechanism by Vgamma9Vdelta2 lymphocytes and a possible link between gammadelta T cell immunity and lipid metabolism are described.

TL;DR: It is reported that obesity-induced insulin resistance in mice precedes macrophage accumulation and inflammation in adipose tissue, and it is suggested that insulin resistant tissue leads to inflammation rather than vice versa.

TL;DR: The monoclonal antibody 9EG7 can functionally distinguish between different beta 1 integrins and defines a beta 1 Integrin other than alpha 4 beta 1 as a newly discovered cell-cell adhesion molecule.