P
Paul Langan
Researcher at Oak Ridge National Laboratory
Publications - 171
Citations - 12825
Paul Langan is an academic researcher from Oak Ridge National Laboratory. The author has contributed to research in topics: Neutron diffraction & Neutron. The author has an hindex of 44, co-authored 170 publications receiving 10983 citations. Previous affiliations of Paul Langan include United States Department of Energy & Keele University.
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A joint x-ray and neutron study on amicyanin reveals the role of protein dynamics in electron transfer
TL;DR: Analysis of the electron transfer path through the protein shows that residues in that region are highly dynamic, as judged by hydrogen/deuterium exchange, which could increase the rate of electron transfer by transiently shortening through-space jumps in pathways or by increasing the atomic packing density.
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Reintroducing electrostatics into macromolecular crystallographic refinement: application to neutron crystallography and DNA hydration.
Timothy D. Fenn,Michael J. Schnieders,Marat Mustyakimov,Chuanjie Wu,Paul Langan,Vijay S. Pande,Axel T. Brunger,Axel T. Brunger +7 more
TL;DR: The inclusion of electrostatics for the force field used for all-atom (including hydrogen) joint neutron/X-ray refinement and a hypothesis for the entropic stabilization of Z-DNA is assessed that may partly explain the thermodynamics of converting the B form of DNA to its Z form.
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Conceptual design of a macromolecular neutron diffractometer (MaNDi) for the SNS
Arthur J. Schultz,Pappannan Thiyagarajan,Jason P. Hodges,Christine Rehm,Dean A. A. Myles,Paul Langan,Andrew D. Mesecar +6 more
TL;DR: In this article, the design criteria, calculations and simulations for a high-resolution macromolecular neutron diffractometer for the Spallation Neutron Source (SNS) were described.
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Controlled incorporation of deuterium into bacterial cellulose
Junhong He,Sai Venkatesh Pingali,Shishir P. S. Chundawat,Angela Pack,A. Daniel Jones,Paul Langan,Brian H. Davison,Volker S. Urban,Barbara R. Evans,Hugh O'Neill +9 more
TL;DR: A media formulation for controlled incorporation of deuterium in bacterial cellulose synthesized by Gluconacetobacter xylinus subsp. sucrofermentans is reported in this article.
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Low- and room-temperature X-ray structures of protein kinase A ternary complexes shed new light on its activity.
Andrey Kovalevsky,Hanna Johnson,B. Leif Hanson,Mary Jo Waltman,S. Zoë Fisher,Susan S. Taylor,Paul Langan +6 more
TL;DR: It was found that ATP can be readily and completely hydrolyzed to ADP and a free phosphate ion in the crystals of the ternary complex PKA-Mg(2)ATP-IP20 by X-ray irradiation at room temperature.