P
Paul M. Matthews
Researcher at Imperial College London
Publications - 641
Citations - 102773
Paul M. Matthews is an academic researcher from Imperial College London. The author has contributed to research in topics: Multiple sclerosis & White matter. The author has an hindex of 140, co-authored 617 publications receiving 88802 citations. Previous affiliations of Paul M. Matthews include John Radcliffe Hospital & King's College London.
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Journal ArticleDOI
Nicotine replacement in abstinent smokers improves cognitive withdrawal symptoms with modulation of resting brain network dynamics
David M. Cole,Christian F. Beckmann,Christian F. Beckmann,Christopher J. Long,Christopher J. Long,Paul M. Matthews,Paul M. Matthews,Michael J. Durcan,John D. Beaver +8 more
TL;DR: It is demonstrated that nicotine administration in abstinent smokers modulates dynamic interactions between large-scale cognitive brain networks in the resting state and suggests that altered functional connectivity patterns of these networks reflect their engagement in reward and salience processing during smoking withdrawal.
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Short‐term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders
TL;DR: It is indicated that short-term DCA treatment not only lowers blood lactate but also improves indices of both brain oxidative metabolism and neuronal and glial density or function.
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Cortical activation changes underlying stimulation-induced behavioural gains in chronic stroke.
Charlotte J. Stagg,Velicia Bachtiar,Jacinta O'Shea,Claire Allman,R A Bosnell,Udo Kischka,Paul M. Matthews,Paul M. Matthews,Heidi Johansen-Berg +8 more
TL;DR: It is shown for the first time that the significant behavioural improvements produced by anodal stimulation to the ipsilesional hemisphere are associated with a functionally relevant increase in activity within the psilesional primary motor cortex in patients with a wide range of disabilities following stroke.
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Combining shape and connectivity analysis: An MRI study of thalamic degeneration in Alzheimer's disease
Mojtaba Zarei,Mojtaba Zarei,Brian Patenaude,Jessica S. Damoiseaux,Ciro Morgese,Steve M. Smith,Paul M. Matthews,Frederik Barkhof,Serge A.R.B. Rombouts,Ernesto J. Sanz-Arigita,Mark Jenkinson +10 more
TL;DR: MRI evidence of regional thalamic degeneration in AD is provided and it is suggested that ventral and dorsal-medial shape change in the thalamus in AD patients is likely to be driven by IML atrophy.
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MRI and clinical studies of facial and bulbar muscle involvement in MuSK antibody-associated myasthenia gravis
Maria Elena Farrugia,Matthew D. Robson,Linda Clover,Phil Anslow,John Newsom-Davis,Robin Kennett,David Hilton-Jones,Paul M. Matthews,Angela Vincent +8 more
TL;DR: The results show that bulbar and facial muscle weakness and wasting are associated with significant muscle atrophy and fatty replacement in MuSK-MG, which was not found in the AChR-MG patients.