Paul M. Matthews

TL;DR: A powerful approach to understanding the clinical significance of this pathology would be to follow changes in vivo, when they can be related directly with symptoms and signs.

TL;DR: The results showed that closely-related biomarkers still contribute uniquely to the prediction of conversion, supporting the continued use of comprehensive biological assessments and nonlinear interaction modelling shows that although for some patients adding additional biomarkers may add little value, for others (i.e., with low hippocampal volume) further invasive and expensive testing is warranted.

TL;DR: The aim is to maximise the benefit of the image data, provided voluntarily by research participants and funded by many organisations, for human health, and provide practical recommendations to enhance creation, use and reuse of neuroimaging data.

TL;DR: FMRI can be used to map increases in blood flow that accompany local synaptic activity in the brain, and applications to neurological impairments that are not associated with structural abnormalities, such as learning problems, dyslexia and movement disorders are likely.

TL;DR: It is shown that elevated mitochondrial ROS increases the degradation of newly synthesized mitochondrial proteins with some proteins more sensitive than others, which may trigger a vicious cycle of mitochondrial ROS production.