F
Florian Kern
Researcher at Brighton and Sussex Medical School
Publications - 146
Citations - 9283
Florian Kern is an academic researcher from Brighton and Sussex Medical School. The author has contributed to research in topics: Cytotoxic T cell & Antigen. The author has an hindex of 40, co-authored 135 publications receiving 8072 citations. Previous affiliations of Florian Kern include Charité & Humboldt University of Berlin.
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Journal ArticleDOI
Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
Andrew W. Sylwester,Bridget L. Mitchell,John B. Edgar,Cara Taormina,Christian Pelte,Franziska Ruchti,Paul R. Sleath,Kenneth H. Grabstein,Nancy Ann Hosken,Florian Kern,Jay A. Nelson,Louis J. Picker +11 more
TL;DR: The first glimpse of the total human T cell response to a complex infectious agent is provided and insight into the rules governing immunodominance and cross-reactivity in complex viral infections of humans is provided.
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SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19.
Julian Braun,Lucie Loyal,Marco Frentsch,Daniel Wendisch,Philipp Georg,Florian Kurth,Florian Kurth,Stefan Hippenstiel,Manuela Dingeldey,Beate Kruse,Florent Fauchere,Emre Baysal,Maike Mangold,Larissa Henze,Roland Lauster,Roland Lauster,Marcus A. Mall,Marcus A. Mall,Kirsten Beyer,Jobst Röhmel,Sebastian Voigt,Jürgen Schmitz,Stefan Miltenyi,Ilja Demuth,Marcel A. Müller,Andreas C. Hocke,Martin Witzenrath,Norbert Suttorp,Florian Kern,Ulf Reimer,Holger Wenschuh,Christian Drosten,Victor M. Corman,Claudia Giesecke-Thiel,Leif E. Sander,Andreas Thiel +35 more
TL;DR: CD4 + T cells that are reactive against the spike glycoprotein of SARS-CoV-2 in the peripheral blood of patients with COVID-19 and healthy donors are found, indicating that spike-protein cross-reactive T cells are present and probably generated during previous encounters with endemic coronaviruses.
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Use of overlapping peptide mixtures as antigens for cytokine flow cytometry
Holden T. Maecker,Holli S Dunn,Maria A. Suni,Elham Khatamzas,Elham Khatamzas,Christine J. Pitcher,Torsten Bunde,Natasha Persaud,Wendy L. Trigona,Tong-Ming Fu,Elizabeth Sinclair,Barry M. Bredt,Joseph M. McCune,Vernon C. Maino,Florian Kern,Louis J. Picker +15 more
TL;DR: Over overlapping 15 amino acid peptide mixes may facilitate the analysis of antigen-specific CD4+ and CD8+ T-cell responses by cytokine flow cytometry, using clinical specimens that include shipped blood or cryopreserved PBMC.
Journal ArticleDOI
Protection from cytomegalovirus after transplantation is correlated with immediate early 1–specific CD8 T cells
Torsten Bunde,Alexander Kirchner,Bodo Hoffmeister,Dirk Habedank,Roland Hetzer,Georgy Cherepnev,Susanna Proesch,Petra Reinke,Hans-Dieter Volk,Hans B. Lehmkuhl,Florian Kern +10 more
TL;DR: High frequencies of IE-1 but not pp65-specific CD8 T cells correlate with protection from CMV disease, which has important implications for monitoring T cell responses, adoptive cell therapy, and vaccine design.
Journal ArticleDOI
Diagnosis of childhood tuberculosis and host RNA expression in Africa.
Suzanne T. Anderson,Myrsini Kaforou,Andrew Brent,Victoria J. Wright,Claire M. Banwell,George Chagaluka,Amelia C. Crampin,Hazel M. Dockrell,Neil French,Melissa Hamilton,Martin L. Hibberd,Florian Kern,Paul R. Langford,Ling Ling,Rachel Mlotha,Tom H. M. Ottenhoff,Sandy Pienaar,Vashini Pillay,J. Anthony G. Scott,Hemed Twahir,Robert J. Wilkinson,Lachlan J. M. Coin,Robert S. Heyderman,Michael Levin,Brian Eley +24 more
TL;DR: RNA expression signatures provided data that helped distinguish tuberculosis from other diseases in African children with and those without HIV infection.