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Paul R. Reynolds
Researcher at Brigham Young University
Publications - 128
Citations - 2597
Paul R. Reynolds is an academic researcher from Brigham Young University. The author has contributed to research in topics: RAGE (receptor) & Medicine. The author has an hindex of 28, co-authored 101 publications receiving 2181 citations. Previous affiliations of Paul R. Reynolds include University of Cincinnati & Cincinnati Children's Hospital Medical Center.
Papers
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Journal ArticleDOI
Midkine is regulated by hypoxia and causes pulmonary vascular remodeling
Paul R. Reynolds,Michael L. Mucenski,Timothy D. Le Cras,William C. Nichols,Jeffrey A. Whitsett +4 more
TL;DR: Data provide a model wherein the respiratory epithelium responds to hypoxia via HIF-1α-dependent regulation of MK, enhancing myocardin expression to influence pulmonary vascular gene expression.
Journal ArticleDOI
Germline hypomorphic CARD11 mutations in severe atopic disease
Chi Ma,Jeffrey R. Stinson,Yuan Zhang,Jordan K. Abbott,Michael A. Weinreich,Pia J. Hauk,Paul R. Reynolds,Jonathan J. Lyons,Celeste G Nelson,Elisa Ruffo,Batsukh Dorjbal,Salomé Glauzy,Natsuko Yamakawa,Swadhinya Arjunaraja,Kelsey Voss,Jennifer Stoddard,Julie E. Niemela,Yu Zhang,Sergio D. Rosenzweig,Joshua J McElwee,Thomas DiMaggio,Helen F. Matthews,Nina Jones,Kelly D. Stone,Alejandro Palma,Matías Oleastro,Emma Prieto,Andrea Bernasconi,Geronimo Dubra,Silvia Danielian,Jonathan Zaiat,Marcelo A. Martí,Brian S. Kim,Megan A. Cooper,Neil Romberg,Eric Meffre,Erwin W. Gelfand,Andrew L. Snow,Joshua D. Milner +38 more
TL;DR: It is shown that a single hypomorphic mutation in CARD11 can cause potentially correctable cellular defects that lead to atopic dermatitis, and this data indicates that monogenic causes for severe manifestations of common allergic diseases have been identified.
Journal ArticleDOI
Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands
Narayanam V. Rao,Brian Argyle,Xiaoyu Xu,Paul R. Reynolds,Jeanine M. Walenga,Margaret Prechel,Glenn D. Prestwich,Robert B. MacArthur,Bradford B. Walters,John R. Hoidal,Thomas P. Kennedy +10 more
TL;DR: It is shown that 2-O and 3-O sulfate groups can be removed to reduce anticoagulant activity of heparin without impairing its anti-inflammatory pharmacology and that 50% inhibitory concentrations of ODSH for these anti- inflammatory activities can be achieved in the blood without antICOagulation.
Journal ArticleDOI
Tracheal Basal cells: a facultative progenitor cell pool.
Brook B. Cole,Russell W. Smith,Kimberly M. Jenkins,Brian B. Graham,Paul R. Reynolds,Susan D. Reynolds +5 more
TL;DR: It is proposed that the hierarchical organization of tracheal reparative cells be revised to include a facultative basal cell progenitor pool and that basal cell proliferation is associated with generation of differentiated Clara and ciliated cells.
Journal ArticleDOI
RAGE: developmental expression and positive feedback regulation by Egr-1 during cigarette smoke exposure in pulmonary epithelial cells
Paul R. Reynolds,Stephen D. Kasteler,Manuel G. Cosio,Anne Sturrock,T. P. Huecksteadt,John R. Hoidal +5 more
TL;DR: Immunohistochemistry demonstrated a temporal-spatial pattern of RAGE expression in pulmonary epithelial cells from embryonic day 17.5 to postnatal day 10 and the likelihood of positive feedback involving Egr-1 and RAGE in cigarette smoke-related disease is indicated.