Celeste G Nelson

TL;DR: It is shown that a single hypomorphic mutation in CARD11 can cause potentially correctable cellular defects that lead to atopic dermatitis, and this data indicates that monogenic causes for severe manifestations of common allergic diseases have been identified.

TL;DR: A broader phenotypic spectrum associated with CARD11 mutations in human subjects is illuminated and the need for functional studies to demonstrate that rare gene variants encountered in expected and unexpected phenotypes must nonetheless be validated for pathogenic activity is underscored.

TL;DR: It is shown that STAT3 negatively regulates TGF-&bgr; signaling via ERBB2-interacting protein (ERBIN), a SMAD anchor for receptor activation and SMAD2/3 binding protein, which can induce expression and activation of the IL-4/IL-4R&agr;/GATA3 axis in vitro.

TL;DR: Although dominant gain‐of‐function mutations in CARD14 are associated with psoriasis and related diseases, loss‐of- function mutations in the same gene are associated in 4 patients with a severe variant of AD.

TL;DR: The results obtained allow us to assess the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds.