P
Paul Steinbach
Researcher at University of California, San Diego
Publications - 20
Citations - 13732
Paul Steinbach is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Cancer & Green fluorescent protein. The author has an hindex of 14, co-authored 20 publications receiving 12920 citations. Previous affiliations of Paul Steinbach include Howard Hughes Medical Institute.
Papers
More filters
Proceedings ArticleDOI
Evaluating and improving the photostability of fluorescent proteins
Nathan C. Shaner,Michael Z. Lin,Michael R. McKeown,Paul Steinbach,Kristin L. Hazelwood,Michael W. Davidson,Roger Y. Tsien +6 more
TL;DR: A method used to measure photostability in live cells under both widefield and confocal laser illumination is standardized and has allowed us to evaluate a large number of commonly used fluorescent proteins, and has uncovered surprisingly complex and unpredictable behaviors in many of these proteins.
Journal ArticleDOI
Spiers Memorial Lecture. Breeding and building molecular spies.
Xiaokun Shu,Varda Lev-Ram,Emilia S. Olson,Todd A. Aguilera,Tao Jiang,M. Whitney,Jessica L. Crisp,Paul Steinbach,T. J. Deerinck,Mark H. Ellisman,Lesley G. Ellies,Quyen T. Nguyen,Roger Y. Tsien +12 more
TL;DR: To circumvent the limited spatial resolution of fluorescent protein imaging, genetically encoded tags for electron microscopy (EM) are developed and shown to have high spatial resolution.
Posted ContentDOI
Structure-function analysis of the maize bulliform cell cuticle and its role in dehydration and leaf rolling
Susanne Matschi,Miguel F. Vasquez,Richard Bourgault,Paul Steinbach,James Chamness,Nicholas Kaczmar,Michael A. Gore,Isabel Molina,Laurie G. Smith +8 more
TL;DR: It is hypothesized that this cell type-specific cuticle of the adult maize leaf epidermis is more water permeable than the epidermal pavement cell cuticle, facilitating the function of bulliform cells in stress-induced leaf rolling observed in grasses.
Journal ArticleDOI
Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent.
Beth Friedman,Michael A. Whitney,Elamprakash N. Savariar,Christa D. Caneda,Paul Steinbach,Qing Xiong,Dina V. Hingorani,Jessica L. Crisp,Stephen R. Adams,Michael Kenner,Csilla N. Lippert,Quyen T. Nguyen,Monica Guma,Roger Y. Tsien,Maripat Corr +14 more
TL;DR: Examination of coagulation protease activities in arthritic mice with a dual‐fluorescence ratiometric activatable cell‐penetrating peptide that has a linker, norleucine (Nle)‐TPRSFL, with a cleavage site for thrombin findsFunctional imaging of synovitis could improve both early detection of rheumatoid arthritis and long‐term outcomes.
Journal ArticleDOI
Visualizing transgenic murine papillary thyroid cancer with novel nerve peptide and protease‐dependent tumor‐targeting peptides
B S Jasper Shen,Michael A. Whitney,B A Jessica Crisp,Tao Jiang,Paul Steinbach,B S Rachel Levins,Roger Y. Tsien,Quyen T. Nguyen +7 more
TL;DR: A way to objectively assess both tumor and nerve margins during surgery and thereby improve the rate of complete tumor removal while minimizing iatrogenic transections of critical nerve structures would benefit patients and may produce significant cost savings.