Paul Williams Biddinger

TL;DR: A novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays and cause efficient tumor shrinkage is reported.

TL;DR: The data indicate that pharmacological inhibition ofFGFR1 kinase activity with ponatinib may be effective for the treatment of lung cancer patients whose tumors overexpress FGFR1.

TL;DR: A case of extrarenal rhabdoid tumor confined to the bladder in a 3-year-old child, diagnosed by histopathology and confirmed by immunohistochemical and molecular studies is reported, only the fourth molecularly proven primary MRT of the bladder to be reported.

TL;DR: The data suggest that nSMase2 activity and ceramide level are critical for lung development and function and that ceramide can no longer be viewed as a lipid solely detrimental to lung function.

TL;DR: Genomic and transcriptomic analysis of >5000 patients demonstrates that KRT8 mutation and copy number amplification are frequently evident in epithelial-derived cancers and binds to annexin A2, a protein known to mediate apoptosis as well as the redox pathway.