P
Pauline M. Wu
Researcher at Brigham and Women's Hospital
Publications - 7
Citations - 3573
Pauline M. Wu is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Microglia & Macrophage. The author has an hindex of 5, co-authored 7 publications receiving 2764 citations. Previous affiliations of Pauline M. Wu include Cleveland Clinic Lerner Research Institute.
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Journal ArticleDOI
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Oleg Butovsky,Mark P. Jedrychowski,Craig S. Moore,Ron Cialic,Amanda J. Lanser,Galina Gabriely,Thomas Koeglsperger,Ben Dake,Pauline M. Wu,Camille Doykan,Zain Fanek,LiPing Liu,Zhuoxun Chen,Jeffrey D. Rothstein,Richard M. Ransohoff,Steven P. Gygi,Jack P. Antel,Howard L. Weiner +17 more
TL;DR: It is found that TGF-β was required for the in vitro development of microglia that express the microglial molecular signature characteristic of adultmicroglia and that microglian were absent in the CNS of TGF -β1–deficient mice.
Journal ArticleDOI
Differential roles of microglia and monocytes in the inflamed central nervous system.
Ryo Yamasaki,Haiyan Lu,Oleg Butovsky,Nobuhiko Ohno,Anna Rietsch,Ron Cialic,Pauline M. Wu,Camille Doykan,Jessica Lin,Anne C. Cotleur,Grahame J. Kidd,Musab M. Zorlu,Nathan Sun,Weiwei Hu,LiPing Liu,Jar Chi Lee,Sarah E. Taylor,Lindsey Uehlein,Lindsey Uehlein,Debra Dixon,Jinyu Gu,Crina M. Floruta,Min Zhu,Israel F. Charo,Howard L. Weiner,Richard M. Ransohoff +25 more
TL;DR: Phagocytic monocyte-derived macrophages associate with the nodes of Ranvier and initiate demyelination while microglia clear debris and display a suppressed metabolic gene signature in EAE.
Journal ArticleDOI
Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
Oleg Butovsky,Shafiuddin Siddiqui,Galina Gabriely,Amanda J. Lanser,Ben Dake,Gopal Murugaiyan,Camille Doykan,Pauline M. Wu,Reddy R. Gali,Lakshmanan K. Iyer,Robert Lawson,James D. Berry,Anna M. Krichevsky,Merit Cudkowicz,Howard L. Weiner +14 more
TL;DR: The results suggest that recruitment of inflammatory monocytes plays an important role in disease progression and that modulation of these cells is a potential therapeutic approach.
Journal ArticleDOI
Erratum: Identification of a unique TGF-β-dependent molecular and functional signature in microglia (Nature Neuroscience (2014) 17 (131-143))
Oleg Butovsky,Mark P. Jedrychowski,Craig S. Moore,Ron Cialic,Amanda J. Lanser,Galina Gabriely,Thomas Koeglsperger,Ben Dake,Pauline M. Wu,Camille Doykan,Zain Fanek,LiPing Liu,Zhuoxun Chen,Jeffrey D. Rothstein,Richard M. Ransohoff,Steven P. Gygi,Jack P. Antel,Howard L. Weiner +17 more
TL;DR: Corrigendum: Identification of a unique TGF-β–dependent molecular and functional signature in microglia and its role in cell reprograming is identified.
Journal ArticleDOI
Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.
Oleg Butovsky,Mark P. Jedrychowski,Ron Cialic,Susanne Krasemann,Gopal Murugaiyan,Zain Fanek,David J. Greco,Pauline M. Wu,Camille Doykan,Olga Kiner,Robert Lawson,Matthew P. Frosch,Nathalie Pochet,Rachid El Fatimy,Anna M. Krichevsky,Steven P. Gygi,Hans Lassmann,James D. Berry,Merit Cudkowicz,Howard L. Weiner +19 more
TL;DR: To investigate miR‐155 in the SOD1 mouse model and human sporadic and familial amyotrophic lateral sclerosis, the objective is to establish an experimental procedure and establish a EMT‐naïve mice model for the disease.