R
Rachid El Fatimy
Researcher at Brigham and Women's Hospital
Publications - 38
Citations - 3327
Rachid El Fatimy is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 17, co-authored 29 publications receiving 2249 citations. Previous affiliations of Rachid El Fatimy include Paris Diderot University & Laval University.
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Journal ArticleDOI
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Susanne Krasemann,Susanne Krasemann,Charlotte Madore,Ron Cialic,Caroline Baufeld,Narghes Calcagno,Rachid El Fatimy,Lien Beckers,Elaine O’Loughlin,Yang Xu,Zain Fanek,David J. Greco,Scott T. Smith,George Tweet,Zachary Humulock,Tobias Zrzavy,Patricia Conde-Sanroman,Mar Gacias,Zhiping Weng,Hao Chen,Emily C. Tjon,Fargol Mazaheri,Kristin Hartmann,Asaf Madi,Jason D. Ulrich,Markus Glatzel,Anna Worthmann,Joerg Heeren,Bogdan Budnik,Cynthia A. Lemere,Tsuneya Ikezu,Frank L. Heppner,Vladimir Litvak,David M. Holtzman,Hans Lassmann,Howard L. Weiner,Jordi Ochando,Christian Haass,Oleg Butovsky +38 more
TL;DR: The TREM2-APOE pathway is identified as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia.
Journal ArticleDOI
Coding and noncoding landscape of extracellular RNA released by human glioma stem cells
Zhiyun Wei,Arsen O. Batagov,Sergio Schinelli,Jintu Wang,Yang Wang,Rachid El Fatimy,Rosalia Rabinovsky,Leonora Balaj,Clark C. Chen,Fred H. Hochberg,Bob S. Carter,Xandra O. Breakefield,Anna M. Krichevsky +12 more
TL;DR: It is suggested that massive EV/exRNA uptake would be required to ensure functional impact of transferred RNA on brain recipient cells and predict the most impactful miRNAs in such conditions and its feasibility on cerebrospinal fluid is validated.
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Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.
Oleg Butovsky,Mark P. Jedrychowski,Ron Cialic,Susanne Krasemann,Gopal Murugaiyan,Zain Fanek,David J. Greco,Pauline M. Wu,Camille Doykan,Olga Kiner,Robert Lawson,Matthew P. Frosch,Nathalie Pochet,Rachid El Fatimy,Anna M. Krichevsky,Steven P. Gygi,Hans Lassmann,James D. Berry,Merit Cudkowicz,Howard L. Weiner +19 more
TL;DR: To investigate miR‐155 in the SOD1 mouse model and human sporadic and familial amyotrophic lateral sclerosis, the objective is to establish an experimental procedure and establish a EMT‐naïve mice model for the disease.
Journal ArticleDOI
A novel function for the survival motoneuron protein as a translational regulator
Gabriel Sanchez,Alain Y. Dury,Lyndsay M. Murray,Olivier Biondi,Helina Tadesse,Rachid El Fatimy,Rashmi Kothary,Rashmi Kothary,Frédéric Charbonnier,Edouard W. Khandjian,Jocelyn Côté +10 more
TL;DR: It is demonstrated that SMN associates with polyribosomes and can repress translation in an in vitro translation system and an SMA-causing mutation in the Tudor domain of SMN completely abolished translational repression, a strong indication for the functional significance of this novel SMN activity in the pathology.
Journal ArticleDOI
Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders
Kazue Hashimoto-Torii,Kazue Hashimoto-Torii,Kazue Hashimoto-Torii,Masaaki Torii,Mitsuaki Fujimoto,Akira Nakai,Rachid El Fatimy,Rachid El Fatimy,Valérie Mezger,Valérie Mezger,Min J. Ju,Seiji Ishii,Shih-hui Chao,Kristen J. Brennand,Fred H. Gage,Pasko Rakic +15 more
TL;DR: It is proposed that HSF1 plays a crucial role in the response of brain cells to prenatal environmental insults and may be a key component in the pathogenesis of late-onset neuropsychiatric disorders.